Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Mechanisms of Choice in X-Chromosome Inactivation

Version 1 : Received: 7 January 2022 / Approved: 12 January 2022 / Online: 12 January 2022 (18:52:02 CET)

How to cite: Furlan, G.; Galupa, R. Mechanisms of Choice in X-Chromosome Inactivation. Preprints 2022, 2022010183 (doi: 10.20944/preprints202201.0183.v1). Furlan, G.; Galupa, R. Mechanisms of Choice in X-Chromosome Inactivation. Preprints 2022, 2022010183 (doi: 10.20944/preprints202201.0183.v1).

Abstract

Early in development, placental and marsupial mammals harbouring at least two X chromosomes per nuclei are faced with a choice that affects the rest of their lives: which of those X chromosomes to transcriptionally inactivate. This choice underlies phenotypical diversity in the composition of tissues and organs and in their response to environment, and can determine whether an individual will be healthy or affected by an X-linked disease. Here, we review our current understanding of the process of choice during X-chromosome inactivation and its implications, focusing on the strategies evolved by different mammalian lineages and on the known and unknown molecular mechanisms and players involved. We also call for a revised manner in which to think about choice during random X-inactivation.

Keywords

X-chromosome inactivation; allelic choice; skewing; placentals; marsupials

Subject

BIOLOGY, Other

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