Review
Version 1
Preserved in Portico This version is not peer-reviewed
Mechanisms of Choice in X-Chromosome Inactivation
Version 1
: Received: 7 January 2022 / Approved: 12 January 2022 / Online: 12 January 2022 (18:52:02 CET)
A peer-reviewed article of this Preprint also exists.
Furlan, G.; Galupa, R. Mechanisms of Choice in X-Chromosome Inactivation. Cells 2022, 11, 535. Furlan, G.; Galupa, R. Mechanisms of Choice in X-Chromosome Inactivation. Cells 2022, 11, 535.
Abstract
Early in development, placental and marsupial mammals harbouring at least two X chromosomes per nuclei are faced with a choice that affects the rest of their lives: which of those X chromosomes to transcriptionally inactivate. This choice underlies phenotypical diversity in the composition of tissues and organs and in their response to environment, and can determine whether an individual will be healthy or affected by an X-linked disease. Here, we review our current understanding of the process of choice during X-chromosome inactivation and its implications, focusing on the strategies evolved by different mammalian lineages and on the known and unknown molecular mechanisms and players involved. We also call for a revised manner in which to think about choice during random X-inactivation.
Keywords
X-chromosome inactivation; allelic choice; skewing; placentals; marsupials
Subject
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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