Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Clinical Manifestation and Diagnostic Process of Celiac Disease in Poland – Comparison of Pediatric and Adult Patients in Retrospective Study

Version 1 : Received: 28 December 2021 / Approved: 29 December 2021 / Online: 29 December 2021 (11:22:00 CET)

How to cite: Majsiak, E.; Choina, M.; Gray, A.M.; Wysokinski, M.; Cukrowska, B. Clinical Manifestation and Diagnostic Process of Celiac Disease in Poland – Comparison of Pediatric and Adult Patients in Retrospective Study. Preprints 2021, 2021120462 (doi: 10.20944/preprints202112.0462.v1). Majsiak, E.; Choina, M.; Gray, A.M.; Wysokinski, M.; Cukrowska, B. Clinical Manifestation and Diagnostic Process of Celiac Disease in Poland – Comparison of Pediatric and Adult Patients in Retrospective Study. Preprints 2021, 2021120462 (doi: 10.20944/preprints202112.0462.v1).

Abstract

The diagnosis of celiac disease (CD) may be delayed due to non-specific clinical symptoms. The aim of the study was to evaluate the clinical manifestation and diagnostic process of CD in Polish children and adults. Methods: The members of the Polish Coeliac Society (n=2 500) were asked to complete a questionnaire on socio-demographic factors, clinical and diagnostic aspects of CD. The analysis was based on 796 responses from patients with confirmed CD diagnosis, and included 224 (28.1%) children and 572 (71.9%) adults. Results: The mean duration of symptoms prior to CD diagnosis in children was significantly shorter than in adults (p < 0.001), and amounted to 3.1 and 9 years respectively. The most frequent symptoms before CD diagnosis were abdominal pain and bloating in children (70.4%), and chronic fatigue in adults (74.5%). Although almost all CD patients claimed to strictly avoid gluten after CD diagnosis, symptoms were still present in the majority of these respondents. No comorbid diseases were reported by 29.8% of children and by 11.7% of adults (p < 0.001). Conclusions: The results indicate that CD diagnosis is delayed in Poland, espe-cially in adults, and clinicians should be aware of the diversity in CD presentation.

Keywords

Celiac disease; diagnostic process; gluten free diet; delayed diagnosis

Subject

MEDICINE & PHARMACOLOGY, Gastroenterology

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