PreprintArticleVersion 1Preserved in Portico This version is not peer-reviewed
Highly Efficient and Diastereoselective Construction of Substituted Pyrrolidines Bearing A Quaternary Carbon Center via 1,3-Dipolar [3 + 2] Cycloaddition
Wang, K.; Li, Y.; Shuai, X.; Chen, R.; Sun, A.; Wang, Z. Highly Efficient and Diastereoselective Construction of Substituted Pyrrolidines Bearing a Quaternary Carbon Center via 1,3‐dipolar Cycloaddition. Journal of Heterocyclic Chemistry 2022, 59, 1616–1625, doi:10.1002/jhet.4494.
Wang, K.; Li, Y.; Shuai, X.; Chen, R.; Sun, A.; Wang, Z. Highly Efficient and Diastereoselective Construction of Substituted Pyrrolidines Bearing a Quaternary Carbon Center via 1,3‐dipolar Cycloaddition. Journal of Heterocyclic Chemistry 2022, 59, 1616–1625, doi:10.1002/jhet.4494.
Wang, K.; Li, Y.; Shuai, X.; Chen, R.; Sun, A.; Wang, Z. Highly Efficient and Diastereoselective Construction of Substituted Pyrrolidines Bearing a Quaternary Carbon Center via 1,3‐dipolar Cycloaddition. Journal of Heterocyclic Chemistry 2022, 59, 1616–1625, doi:10.1002/jhet.4494.
Wang, K.; Li, Y.; Shuai, X.; Chen, R.; Sun, A.; Wang, Z. Highly Efficient and Diastereoselective Construction of Substituted Pyrrolidines Bearing a Quaternary Carbon Center via 1,3‐dipolar Cycloaddition. Journal of Heterocyclic Chemistry 2022, 59, 1616–1625, doi:10.1002/jhet.4494.
Abstract
A general approach to substituted pyrrolidines via [3 + 2] 1,3-dipolar cycloaddition between nonstabilized azomethine ylides and cyanosulfones was developed. The efficient method provides a series of substituted pyrrolidines bearing a quaternary carbon center in high yields (up to 98%) excellent diastereoselectivities (up to >25:1 dr) under ambient reaction conditions.
Chemistry and Materials Science, Organic Chemistry
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
