Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Assessment of the Effectiveness of Obstructive Sleep Apnea Treatment Using Optical Coherence Tomography to Evaluate Retinal Findings

Gloria Tejero-Garcés
,
Francisco J Ascaso
ORCID logo ,
Paula Casas
,
Maria I Adiego
,
Peter Baptista
ORCID logo ,
Carlos O'Connor-Reina
,
Eugenio Vicente
,
Guillermo Plaza
*
Version 1 : Received: 15 December 2021 / Approved: 17 December 2021 / Online: 17 December 2021 (08:47:15 CET)

A peer-reviewed article of this Preprint also exists.

Tejero-Garcés, G.; Ascaso, F.J.; Casas, P.; Adiego, M.I.; Baptista, P.; O’Connor-Reina, C.; Vicente, E.; Plaza, G. Assessment of the Effectiveness of Obstructive Sleep Apnea Treatment Using Optical Coherence Tomography to Evaluate Retinal Findings. J. Clin. Med. 2022, 11, 815. Tejero-Garcés, G.; Ascaso, F.J.; Casas, P.; Adiego, M.I.; Baptista, P.; O’Connor-Reina, C.; Vicente, E.; Plaza, G. Assessment of the Effectiveness of Obstructive Sleep Apnea Treatment Using Optical Coherence Tomography to Evaluate Retinal Findings. J. Clin. Med. 2022, 11, 815.

Abstract

Retinal findings may change in patients with obstructive sleep apnea syndrome (OSAS). The present study aims to evaluate several retinal findings such as macula layer thickness, peripapillary retinal nerve fiber layer, and the optic nerve head in patients with OSAS using optical coherence tomography (OCT) and monitor the result of several types of treatment of OSAS with OCT. A prospective comparative study was designed. Patients were recruited at a Sleep Unit of a University Hospital and underwent comprehensive ophthalmological examinations. Following exclusion criteria, fifty-two patients with OSAS were finally included. Patients were examined by OCT twice: first, before treatment; secondly, after six months of treatment. In mild-moderate patients, where retinal swelling has been demonstrated, retinal thicknesses decreased [fovea (p=0.026), as well as inner ring macula (p=0.007), outer ring macula (p=0.015), and macular volume (p=0.015)]. In severe patients, where retinal atrophy had been observed, retinal thickness increased [fovea (p<0.001)]. No statistically significant differences in efficacy between treatments were demonstrated. In conclusion, OCT can evaluate the retina in patients with OSAS and help monitor results after treatment. In severe OSAS, retinal thickness increased six months after treatment.

Keywords

Retina; Retinal nerve fiber layer; Obstructive sleep apnea syndrome; Optical coherence tomography; OCT; CPAP; Upper airway surgery.

Subject

Medicine and Pharmacology, Pulmonary and Respiratory Medicine

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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