Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Incidence of Histoplasmosis in a Cohort of People with HIV: From Estimations to Reality

Narda Medina
ORCID logo ,
Juan Luis Rodriguez-Tudela
,
Luis Aguirre
* ,
Luis R Salazar
ORCID logo ,
Osmar Gamboa
ORCID logo ,
Oscar Bonilla
,
Juan C Pérez
,
Eduardo Arathoon
ORCID logo ,
David W Denning
ORCID logo ,
Ana Alastruey-Izquierdo
* ORCID logo
Version 1 : Received: 16 November 2021 / Approved: 17 November 2021 / Online: 17 November 2021 (12:44:23 CET)

A peer-reviewed article of this Preprint also exists.

Medina, N.; Rodriguez-Tudela, J.L.; Aguirre, L.; Salazar, L.R.; Gamboa, O.; Bonilla, O.; Pérez, J.C.; Arathoon, E.; Denning, D.W.; Alastruey-Izquierdo, A. Incidence of Histoplasmosis in a Cohort of People with HIV: From Estimations to Reality. Microorganisms 2021, 9, 2596. Medina, N.; Rodriguez-Tudela, J.L.; Aguirre, L.; Salazar, L.R.; Gamboa, O.; Bonilla, O.; Pérez, J.C.; Arathoon, E.; Denning, D.W.; Alastruey-Izquierdo, A. Incidence of Histoplasmosis in a Cohort of People with HIV: From Estimations to Reality. Microorganisms 2021, 9, 2596.

Abstract

Among people with HIV, histoplasmosis represents an important cause of mortality. Previous studies have provided estimates of the disease incidence. Here, we compared those estimates with the results obtained from a screening program implemented in Guatemala, which included histoplasmosis detection for people with HIV. To compare the results of this program, with previous estimations, a literature search was done and reports about histoplasmosis incidence were analyzed. The screening program enrolled 6,366 patients. The overall histoplasmosis incidence in the screening program was 7.4%, which was almost double than those estimated by the previous studies. From 2017 to 2019, the screening program showed an upward trend in histoplasmosis cases from 6.5% to 8.8%. Histoplasmosis overall mortality among those who were newly HIV diagnosed showed a decrease at 180 days from 32.8% in 2017 to 21.2% in 2019. The screening approach using rapid diagnostic assays detects quickly more cases of histoplasmosis, allowing a specific treatment, which decreases the mortality of the disease. Therefore, the use of these new techniques, especially in endemic areas of histoplasmosis, must be implemented.

Keywords

Histoplasmosis; Antigen; HIV; Opportunistic infections

Subject

Medicine and Pharmacology, Immunology and Allergy

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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