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MRI CNS Atrophy Pattern and the Etiologies of Progressive Ataxias
Version 1
: Received: 9 November 2021 / Approved: 12 November 2021 / Online: 12 November 2021 (11:37:40 CET)
A peer-reviewed article of this Preprint also exists.
Mascalchi, M. MRI CNS Atrophy Pattern and the Etiologies of Progressive Ataxias. Tomography 2022, 8, 423-437. Mascalchi, M. MRI CNS Atrophy Pattern and the Etiologies of Progressive Ataxias. Tomography 2022, 8, 423-437.
Abstract
MRI shows in-vivo the three archetypal patterns of CNS volume loss underlying progressive ataxias, namely spinal atrophy (SA), cortical cerebellar atrophy (CCA) and olivopontocerebellar atrophy (OPCA). The MRI-based CNS atrophy pattern was reviewed in 128 progressive ataxias. A CNS atrophy pattern was identified in 91 conditions: SA in Freidreich’s ataxia, CCA in 5 acquired and 72 (24 dominant, 47 recessive,1 X-linked) inherited ataxias, OPCA in Multi-System Atrophy and 12 (9 dominant, 2 recessive,1 X-linked) inherited ataxias. The MRI-based CNS atrophy pattern may be useful for genetic assessment, identification of shared cellular targets, and repurposing therapies or enlargement of drugs indications in progressive ataxias.
Keywords
Ataxia; MRI; CNS
Subject
Medicine and Pharmacology, Neuroscience and Neurology
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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