Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Halogen-Furan-2(5H)-One Derivatives Decrease Biofilm Production in Pseudomonas aeruginosa.

Version 1 : Received: 3 November 2021 / Approved: 4 November 2021 / Online: 4 November 2021 (16:18:19 CET)

How to cite: Aburto-Rodríguez, N.A.; García-Contreras, R.; Castillo-Juárez, I.; Castro-Torres, V.A.; Martínez-Vázquez, M. Halogen-Furan-2(5H)-One Derivatives Decrease Biofilm Production in Pseudomonas aeruginosa.. Preprints 2021, 2021110105 (doi: 10.20944/preprints202111.0105.v1). Aburto-Rodríguez, N.A.; García-Contreras, R.; Castillo-Juárez, I.; Castro-Torres, V.A.; Martínez-Vázquez, M. Halogen-Furan-2(5H)-One Derivatives Decrease Biofilm Production in Pseudomonas aeruginosa.. Preprints 2021, 2021110105 (doi: 10.20944/preprints202111.0105.v1).

Abstract

Clinical evidence has shown that bacterial infections are more difficult to eradicate when form-ing a biofilm aggregate than when are produced by bacteria in planktonic form. Therefore, com-pounds that inhibit biofilm formation could be used against severe infections. It has been re-ported that bromo 2-(5H) furanones inhibited biofilm formation by their anti-quorum sensing properties. To determine if the 2-(5H) furanone moiety is essential to induce inhibition of biofilm formation, we evaluated ten halogen 2-(5H) furanones derivates previously synthesized. Besides evaluating the inhibition of biofilm formation, we assessed pyocyanin production, swarming motility, and transcription of essential QS genes: rsaL, rhlA, pqsA and phz1 genes. Our results showed that although three bromo-furan-2(5H)-one-type derivatives (A1-A3) and two bromo-4-(phenylamino)-furan-2(5H)-one-type compounds (B2 and B6) inhibited the biofilm formation in both P. aeruginosa PA14 (reference) and PA64 (drug-resistant) strains only the furanones A1-A3 were efficient to inhibit QSS.

Keywords

quorum sensing; furanones; biofilm

Subject

CHEMISTRY, Medicinal Chemistry

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our diversity statement.

Leave a public comment
Send a private comment to the author(s)
Views 0
Downloads 0
Comments 0
Metrics 0


×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.