Aburto-Rodríguez, N.A.; García-Contreras, R.; Castillo-Juárez, I.; Castro-Torres, V.A.; Martínez-Vázquez, M. Halogen-Furan-2(5H)-One Derivatives Decrease Biofilm Production in Pseudomonas aeruginosa.. Preprints2021, 2021110105. https://doi.org/10.20944/preprints202111.0105.v1
APA Style
Aburto-Rodríguez, N.A., García-Contreras, R., Castillo-Juárez, I., Castro-Torres, V.A., & Martínez-Vázquez, M. (2021). Halogen-Furan-2(5H)-One Derivatives Decrease Biofilm Production in Pseudomonas aeruginosa.. Preprints. https://doi.org/10.20944/preprints202111.0105.v1
Chicago/Turabian Style
Aburto-Rodríguez, N.A., Victor Alberto Castro-Torres and Mariano Martínez-Vázquez. 2021 "Halogen-Furan-2(5H)-One Derivatives Decrease Biofilm Production in Pseudomonas aeruginosa." Preprints. https://doi.org/10.20944/preprints202111.0105.v1
Abstract
Clinical evidence has shown that bacterial infections are more difficult to eradicate when form-ing a biofilm aggregate than when are produced by bacteria in planktonic form. Therefore, com-pounds that inhibit biofilm formation could be used against severe infections. It has been re-ported that bromo 2-(5H) furanones inhibited biofilm formation by their anti-quorum sensing properties. To determine if the 2-(5H) furanone moiety is essential to induce inhibition of biofilm formation, we evaluated ten halogen 2-(5H) furanones derivates previously synthesized. Besides evaluating the inhibition of biofilm formation, we assessed pyocyanin production, swarming motility, and transcription of essential QS genes: rsaL, rhlA, pqsA and phz1 genes. Our results showed that although three bromo-furan-2(5H)-one-type derivatives (A1-A3) and two bromo-4-(phenylamino)-furan-2(5H)-one-type compounds (B2 and B6) inhibited the biofilm formation in both P. aeruginosa PA14 (reference) and PA64 (drug-resistant) strains only the furanones A1-A3 were efficient to inhibit QSS.
Keywords
quorum sensing; furanones; biofilm
Subject
Chemistry and Materials Science, Medicinal Chemistry
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
