Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Neurogenic Inflammation: One of the Participants of Migraine and the Contribution of Translational Research

Version 1 : Received: 2 November 2021 / Approved: 3 November 2021 / Online: 3 November 2021 (08:30:58 CET)

How to cite: Spekker, E.; Tanaka, M.; Szabó, Á.; Vécsei, L. Neurogenic Inflammation: One of the Participants of Migraine and the Contribution of Translational Research. Preprints 2021, 2021110064 (doi: 10.20944/preprints202111.0064.v1). Spekker, E.; Tanaka, M.; Szabó, Á.; Vécsei, L. Neurogenic Inflammation: One of the Participants of Migraine and the Contribution of Translational Research. Preprints 2021, 2021110064 (doi: 10.20944/preprints202111.0064.v1).

Abstract

Migraine is a primary headache disorder characterized by unilateral throbbing, pulsing headache, which lasts for hours to days, and the pain can interfere with daily activities. It exhibits various symptoms, such as nausea, vomiting, sensitivity to light, sound, and odors and physical activity consistently contributes to worsening pain. Despite the intensive research, little is still known about the pathomechanism of migraine. It is widely accepted that migraine involves activation and sensitization of the trigeminovascular system. It leads to the release of several pro-inflammatory neuropeptides and neurotransmitters and causes a cascade of inflammatory tissue responses including vasodilation, plasma extravasation secondary to capillary leakage, edema, and mast cell degranulation. Convincing evidence obtained in rodent models suggests that neurogenic inflammation is assumed to contribute to the development of a migraine attack. Chemical stimulation of the dura mater triggers activation and sensitization of the trigeminal system and causes numerous molecular and behavioral changes; therefore, this is a relevant animal model of acute migraine. This review article discusses the emerging evidence supporting the involvement of neurogenic inflammation and neuropeptides in the pathophysiology of migraine, presenting the most recent advances in preclinical research and the novel therapeutic approaches to the disease.

Keywords

primary headache; migraine; trigeminal system; neuropeptides; neurogenic inflammation; animal model; inflammatory soup; dura mater; immune system; migraine treatment

Subject

MEDICINE & PHARMACOLOGY, Other

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