Preprint Concept Paper Version 1 Preserved in Portico This version is not peer-reviewed

Precision Public Health Through Serological Biomarkers: An Integrated Surveillance Platform to Inform Public Health Interventions

Version 1 : Received: 27 October 2021 / Approved: 28 October 2021 / Online: 28 October 2021 (15:51:43 CEST)

How to cite: Wiens, K.E.; Jauregui, B.; Arnold, B.F.; Banke, K.; Wade, D.; Hayford, K.; Costero-Saint Denis, A.; Hall, R.H.; Salje, H.; Rodriguez-Barraquer, I.; Azman, A.S.; Vernet, G.; Leung, D.T. Precision Public Health Through Serological Biomarkers: An Integrated Surveillance Platform to Inform Public Health Interventions. Preprints 2021, 2021100444 (doi: 10.20944/preprints202110.0444.v1). Wiens, K.E.; Jauregui, B.; Arnold, B.F.; Banke, K.; Wade, D.; Hayford, K.; Costero-Saint Denis, A.; Hall, R.H.; Salje, H.; Rodriguez-Barraquer, I.; Azman, A.S.; Vernet, G.; Leung, D.T. Precision Public Health Through Serological Biomarkers: An Integrated Surveillance Platform to Inform Public Health Interventions. Preprints 2021, 2021100444 (doi: 10.20944/preprints202110.0444.v1).

Abstract

The use of biomarkers to measure immune responses in serum is crucial for understanding population-level exposure and susceptibility to human pathogens. Advances in sample collection, multiplex testing, and computational modeling are transforming serosurveillance into a powerful tool for public health program design and response to infectious threats. In July 2018, 70 scientists from 20 countries met to perform a landscape analysis of approaches that support an integrated serosurveillance platform, including the consideration of issues for successful implementation. Here, we summarize the group’s insights and proposed roadmap for implementation, including objectives, technical requirements, ethical issues, logistical considerations, and monitoring and evaluation.

Keywords

serology; biomarkers; serosurveillance; sero-epidemiology; precision public health

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