Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Exploring Chemical Diversity of Phorbas Sponges as a Source of Novel Lead Compounds in Drug Discovery

Alessia Caso
ORCID logo ,
Fernanda Barbosa da Silva
,
Germana Esposito
ORCID logo ,
Roberta Teta
ORCID logo ,
Gerardo Della Sala
,
Laura P. A. Nunes Cavalcanti
,
Alessandra Leda Valverde
,
Roberto Carlos C. Martins
ORCID logo ,
Valeria Costantino
* ORCID logo
Version 1 : Received: 24 October 2021 / Approved: 25 October 2021 / Online: 25 October 2021 (13:16:55 CEST)

A peer-reviewed article of this Preprint also exists.

Caso, A.; da Silva, F.B.; Esposito, G.; Teta, R.; Sala, G.D.; Cavalcanti, L.P.A.N.; Valverde, A.L.; Martins, R.C.C.; Costantino, V. Exploring Chemical Diversity of Phorbas Sponges as a Source of Novel Lead Compounds in Drug Discovery. Mar. Drugs 2021, 19, 667. Caso, A.; da Silva, F.B.; Esposito, G.; Teta, R.; Sala, G.D.; Cavalcanti, L.P.A.N.; Valverde, A.L.; Martins, R.C.C.; Costantino, V. Exploring Chemical Diversity of Phorbas Sponges as a Source of Novel Lead Compounds in Drug Discovery. Mar. Drugs 2021, 19, 667.

Abstract

Porifera, commonly referred to as marine sponges, have stood out as major producers of marine natural products (MNPs). Sponges of the genus Phorbas have attracted much attention along years. They are widespread in all continents, and several structurally unique compounds have been identified from species of this genus. Terpenes, mainly sesterterpenoids, represent the great majority of secondary metabolites isolated from Phorbas species, even though several alkaloids and steroids have also been reported. Many of these compounds have shown a variety of biological activities. Particularly, Phorbas sponges have been demonstrated to be a source of cytotoxic metabolites. In addition, MNPs exhibiting cytostatic, antimicrobial and anti-inflammatory activities, have been isolated and structurally characterized. This work brings an overview of Phorbas secondary metabolites reported since the first study published in 1993 until 2020, and their biological activities.

Keywords

Phorbas; marine sponges; marine natural products (MNPs); bioactivity,; cytotoxic metabolites; antimicrobial and anti-inflammatory activities; sesterterpene

Subject

Chemistry and Materials Science, Organic Chemistry

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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