Version 1
: Received: 22 October 2021 / Approved: 25 October 2021 / Online: 25 October 2021 (12:50:03 CEST)
How to cite:
Roy, D.; Bandla, R.; Boddana, P.; Medisetty, R.; Gogada, R. Role of MiRNAs and It’s Single Nucleotide Polymorphism in Breast Cancer. Preprints2021, 2021100349. https://doi.org/10.20944/preprints202110.0349.v1.
Roy, D.; Bandla, R.; Boddana, P.; Medisetty, R.; Gogada, R. Role of MiRNAs and It’s Single Nucleotide Polymorphism in Breast Cancer. Preprints 2021, 2021100349. https://doi.org/10.20944/preprints202110.0349.v1.
Cite as:
Roy, D.; Bandla, R.; Boddana, P.; Medisetty, R.; Gogada, R. Role of MiRNAs and It’s Single Nucleotide Polymorphism in Breast Cancer. Preprints2021, 2021100349. https://doi.org/10.20944/preprints202110.0349.v1.
Roy, D.; Bandla, R.; Boddana, P.; Medisetty, R.; Gogada, R. Role of MiRNAs and It’s Single Nucleotide Polymorphism in Breast Cancer. Preprints 2021, 2021100349. https://doi.org/10.20944/preprints202110.0349.v1.
Abstract
MiRNAs are 20-22 nucleotide long single-stranded non-coding RNA sequences, which can regulate post transcriptional activity of mRNA by binding with it at 3’UTR region (untranslated region). Thus deregulation of miRNA expression is responsible for dysregulating mRNA function which contributes in developing various diseases as well as cancerous phenotypes. Alteration of single nucleotide in miRNA sequence is one of the reasons behind deregulation of miRNA expression. The most frequent carcinoma in current day is breast cancer which causes a high mortality among women around the world as well as India. Despite of the advancement of diagnostic tools, strategies and treatment, the cases of breast cancer is increasing every year. There are plenty of biomarkers like ER, PR, Her2, Ki-67, etc available which are frequently used in diagnosis and treatment of breast cancer. After the discovery of MiRNA in 1993 in Caenorhabiditis elegans, it is attracting all the limelight in diagnosis and treatment of different carcinomas as well as breast cancer. In this review we will discuss on involvement of different types of MiRNAs and miR SNPs in breast cancer occurrence and susceptibility in a detailed manner.
Keywords
microRNA; SNP’s; breast cancer; RNA induced silencing complex
Subject
LIFE SCIENCES, Biochemistry
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
