Preprint
Review
What We Know About Kininogen Structure – Importance for Function and Perspectives from Cryo-EM
This version is not peer-reviewed.
Submitted:
30 October 2021
Posted:
01 November 2021
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Abstract
Kininogens are multidomain glycoproteins found in the blood of most vertebrates. They are important in the blood coagulation cascade pathways - in intrinsic pathway activation leading to thrombin generation partially independently from tissue factor dependent extrinsic pathway, connecting blood coagulation with the kallikrein-kinin system. Nothing is known about the shape on atomic level therefore the endeavor to obtain the good-quality spatial structure of kininogens is important for a better understanding of their role in disease and treatment. Application of cryo-EM is important for solving the spatial structure of kininogens, drawing new frontiers in understanding the function and opening new pathways for drug development.
Keywords:
kininogen
; structure
; AlphaFold
; cryo-EM
; proteins
; kinin
; bradykinin
Copyright: This open access article is published under a Creative Commons CC BY 4.0 license, which permit the free download, distribution, and reuse, provided that the author and preprint are cited in any reuse.
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