Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Magnetic Resonance Imaging in Animal Models of Alzheimer’s Disease Amyloidosis

Version 1 : Received: 14 October 2021 / Approved: 15 October 2021 / Online: 15 October 2021 (15:06:55 CEST)

A peer-reviewed article of this Preprint also exists.

Ni, R. Magnetic Resonance Imaging in Animal Models of Alzheimer’s Disease Amyloidosis. Int. J. Mol. Sci. 2021, 22, 12768. Ni, R. Magnetic Resonance Imaging in Animal Models of Alzheimer’s Disease Amyloidosis. Int. J. Mol. Sci. 2021, 22, 12768.

Journal reference: Int. J. Mol. Sci. 2021, 22, 12768
DOI: 10.3390/ijms222312768

Abstract

Amyloid-beta plays an important role in the pathogenesis of Alzheimer’s disease. Aberrant amyloid-beta and tau accumulation induce neuroinflammation, cerebrovascular alterations, synaptic deficits, functional deficits, and neurodegeneration, leading to cognitive impairment. Animal models recapitulating the amyloid-beta pathology such as transgenic, knock-in mouse and rat models have facilitated the understanding of disease mechanisms and development of therapeutics targeting at amyloid-beta. There is a rapid advance in high-field MR in small animals. Versatile high-field magnetic resonance imaging (MRI) sequences such as diffusion tensor imaging, arterial spin labelling, resting-state functional MRI, anatomical MRI, MR spectroscopy as well as contrast agents have been developed for the applications in animal models. These tools have enabled high-resolution in vivo structural, functional, and molecular readouts with a whole brain field-of-view. MRI have been utilized to visualize non-invasively the amyloid-beta deposits, synaptic deficits, regional brain atrophy, impairment in white matter integrity, functional connectivity, cerebrovascular and glymphatic system in animal models of amyloidosis. Many of the readouts are translational in clinical MRI in the brain of patients with Alzheimer’s disease. In this review, we summarize the recent advance of using MRI for visualizing the pathophysiology in amyloidosis animal model. We discuss the outstanding challenges in brain imaging using MRI in small animal and propose future outlook in visualizing amyloid-beta-related alterations in brain of animal models.

Keywords

Alzheimer’s disease; magnetic resonance imaging; animal model; amyloid-beta

Subject

LIFE SCIENCES, Other

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