da Silva, E.M.; Vidal, H.D.A.; Corrêa, A.G. Advances on Greener Asymmetric Synthesis of Antiviral Drugs via Organocatalysis. Pharmaceuticals2021, 14, 1125.
da Silva, E.M.; Vidal, H.D.A.; Corrêa, A.G. Advances on Greener Asymmetric Synthesis of Antiviral Drugs via Organocatalysis. Pharmaceuticals 2021, 14, 1125.
da Silva, E.M.; Vidal, H.D.A.; Corrêa, A.G. Advances on Greener Asymmetric Synthesis of Antiviral Drugs via Organocatalysis. Pharmaceuticals2021, 14, 1125.
da Silva, E.M.; Vidal, H.D.A.; Corrêa, A.G. Advances on Greener Asymmetric Synthesis of Antiviral Drugs via Organocatalysis. Pharmaceuticals 2021, 14, 1125.
Abstract
Viral infections inflict many serious human diseases, being responsible for remarkably high mortality rates. In this sense, both the academy and the pharmaceutical industry are continuously searching for new compounds with antiviral activity, and in addition, face the challenge of developing greener and more efficient methods to synthesize these compounds. This becomes even more important with drugs possessing stereogenic centers as highly enantioselective processes are required. In this minireview, the advances achieved to improve synthetic routes efficiency and sustainability of important commercially antiviral chiral drugs are discussed, highlighting the use of organocatalytic methods.
Keywords
antivirals; green chemistry; selectivity; asymmetric synthesis; organocatalysis
Subject
Chemistry and Materials Science, Organic Chemistry
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
