Version 1
: Received: 24 September 2021 / Approved: 27 September 2021 / Online: 27 September 2021 (15:07:48 CEST)
Version 2
: Received: 8 November 2021 / Approved: 10 November 2021 / Online: 10 November 2021 (14:29:43 CET)
Version 3
: Received: 16 May 2022 / Approved: 16 May 2022 / Online: 16 May 2022 (15:22:13 CEST)
Skwierawska, D., López-Valverde, J. A., Balcerzyk, M., & Leal, A. (2022). Clinical Viability of Boron Neutron Capture Therapy for Personalized Radiation Treatment. Cancers, 14(12), 2865.
Skwierawska, D., López-Valverde, J. A., Balcerzyk, M., & Leal, A. (2022). Clinical Viability of Boron Neutron Capture Therapy for Personalized Radiation Treatment. Cancers, 14(12), 2865.
Skwierawska, D., López-Valverde, J. A., Balcerzyk, M., & Leal, A. (2022). Clinical Viability of Boron Neutron Capture Therapy for Personalized Radiation Treatment. Cancers, 14(12), 2865.
Skwierawska, D., López-Valverde, J. A., Balcerzyk, M., & Leal, A. (2022). Clinical Viability of Boron Neutron Capture Therapy for Personalized Radiation Treatment. Cancers, 14(12), 2865.
Abstract
Boron Neutron Capture Therapy (BNCT) is a promising binary disease-targeted therapy, as neutrons preferentially kill cells labeled with boron (10B), which makes it a precision medicine treatment modality that provides a therapeutic effect exclusively on patient-specific tumor spread. Contrary to what is usual in radiotherapy, BNCT proposes cell-tailored treatment planning rather than to the tumor mass. The success of BNCT depends mainly on the sufficient spatial biodistribution of 10B located around or within neoplastic cells to produce a high-dose gradient between the tumor and healthy tissue. However, it is not yet possible to precisely determine the concentration of 10B in a specific tissue in real-time using noninvasive methods. Critical issues remain to be resolved if BNCT is to become a valuable, minimally invasive, and efficient treatment. Moreover, functional imaging technologies such as PET can be applied to determine biological information that can be used for the combined-modality radiotherapy protocol for each specific patient. Anyway, not only imaging methods but also proteomics and gene expression methods will facilitate BNCT becoming a modality of personalized medicine. This work provides an overview of the fundamental principles, recent advances, and future directions of BNCT as cell-targeted cancer therapy for personalized radiation treatment.
Medicine and Pharmacology, Oncology and Oncogenics
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Commenter: Marcin Balcerzyk
Commenter's Conflict of Interests: Author