Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Copolymerization of Quinazolinone Derivatives With Styrene, Methyl Methacrylate and Their Silver Nanocomposites for Biological Applications

Version 1 : Received: 15 September 2021 / Approved: 17 September 2021 / Online: 17 September 2021 (12:11:48 CEST)

How to cite: El-Said, K.S.; El-Barbary, A.A.; ElKholy, H.M.; Haidyrah, A.S.; Betiha, M.; Batiha, G.E.; Mahmoud, M.H.; Abdelwahab, M.A. Copolymerization of Quinazolinone Derivatives With Styrene, Methyl Methacrylate and Their Silver Nanocomposites for Biological Applications. Preprints 2021, 2021090311 (doi: 10.20944/preprints202109.0311.v1). El-Said, K.S.; El-Barbary, A.A.; ElKholy, H.M.; Haidyrah, A.S.; Betiha, M.; Batiha, G.E.; Mahmoud, M.H.; Abdelwahab, M.A. Copolymerization of Quinazolinone Derivatives With Styrene, Methyl Methacrylate and Their Silver Nanocomposites for Biological Applications. Preprints 2021, 2021090311 (doi: 10.20944/preprints202109.0311.v1).

Abstract

Reaction of 2-mercapto-3-phenylquinazolin-4(3H)-one (MPQ) with both 4-vinyl benzyl chloride and allyl bromide furnished the reactive heterocyclic monomers 3-phenyl-2-((4-vinylbenzyl) thio) quinazolin-4(3H)-one (PVTQ) and 2-(allylthio)-3-phenylquinazolin-4(3H)-one (APQ), respectively. Copolymerization of PVTQ monomer with styrene and methyl methacrylate in the presence of 2,2′-azobisisobutyronitrile (AIBN) afforded the copolymers PS-co-PPVTQ and PMMA-co-PPVTQ, respectively. Similarly, copolymerization of monomer APQ with styrene and methyl methacrylate (MMA) afforded the copolymers PS-co-PAPQ and PMMA-co-PAPQ, respectively. The resulted copolymers were characterized by using FT-IR, 1H-NMR and GPC techniques. Silver nanocomposites of PS, PMMA, PS-co-PPVTQ, PMMA-co-PPVTQ, PS-co-PAPQ and PMMA-co-PAPQ were synthesized by the addition of silver nitrate into the polymer solution. The reduction of silver ions into silver nanoparticles was performed in DMF and water. Thermogravimetric (TGA) analysis was used to determine the thermal stability of the copolymers and their silver nanocomposites. The X-ray diffraction (XRD) analysis indicated the amorphous structures of the co-polymers and confirmed the formation of silver nanoparticles. The antitumor and antibacterial activities were screened for the copolymers and enhanced by the formation of their silver nanocomposites. In vivo antitumor activity in Ehrlich Ascitic Carcinoma (EAC) mice model showed that PS-co-PPVTQ/Ag NPs, PMMA-co-PPVTQ/Ag NPs, and PMMA-co-PAPQ/Ag NPs displayed promising inhibitory effects against EAC and induce apoptosis against MCF-7 cells.

Keywords

Quinazolinone; Styrene; Methacrylate; Nano-silver; Antibacterial; Antitumor.

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