Preprint Article Version 2 Preserved in Portico This version is not peer-reviewed

Schizophrenia and Hospital Admissions for Cardiovascular Events in a Large Population. The APNA Study

Sara Guillen-Aguinaga
ORCID logo ,
Antonio Brugos-Larumbe
,
Laura Guillen-Aguinaga
ORCID logo ,
Felipe Ortuño
,
Francisco Guillen-Grima
* ORCID logo ,
Luis Forga
ORCID logo ,
Ines Aguinaga-Ontoso
ORCID logo
Version 1 : Received: 14 September 2021 / Approved: 15 September 2021 / Online: 15 September 2021 (11:35:44 CEST)
Version 2 : Received: 28 December 2021 / Approved: 30 December 2021 / Online: 30 December 2021 (19:42:41 CET)

A peer-reviewed article of this Preprint also exists.

Guillen-Aguinaga, S.; Brugos-Larumbe, A.; Guillen-Aguinaga, L.; Ortuño, F.; Guillen-Grima, F.; Forga, L.; Aguinaga-Ontoso, I. Schizophrenia and Hospital Admissions for Cardiovascular Events in a Large Population: The APNA Study. J. Cardiovasc. Dev. Dis. 2022, 9, 25. Guillen-Aguinaga, S.; Brugos-Larumbe, A.; Guillen-Aguinaga, L.; Ortuño, F.; Guillen-Grima, F.; Forga, L.; Aguinaga-Ontoso, I. Schizophrenia and Hospital Admissions for Cardiovascular Events in a Large Population: The APNA Study. J. Cardiovasc. Dev. Dis. 2022, 9, 25.

Abstract

(1) Background: Patients with schizophrenia have higher mortality, with cardiovascular diseases being the first cause of mortality. This study aims to estimate the excess risk of hospital admission for cardiovascular events in schizophrenic patients, adjusting for comorbidity and risk factors. (2) Methods: The APNA study is a dynamic prospective cohort of all residents in Navarra, Spain. 505889 people over 18 years were followed for five years. The endpoint was hospital admissions for a cardiovascular event. Direct Acyclic Graphs (DAG) and Cox regression were used. (3) Results: Schizophrenic patients had a Hazard Ratio (HR) of 1.414 (95% CI 1.031-1.938) of hospital admission for a cardiovascular event after adjusting for age, sex, hypertension, type 2 diabetes, dyslipidemia, smoking, low income, obesity, antecedents of cardiovascular disease, and smoking. In non-adherent to antipsychotic treatment schizophrenia patients, the HR was 2.232 (95% CI 1.267-3.933). (4) Conclusions: Patients with schizophrenia have a higher risk of hospital admission for cardiovascular events than persons with the same risk factors without schizophrenia. Primary care nursing interventions should monitor these patients and reduce cardiovascular risk factors.

Keywords

cardiovascular; schizophrenia; prospective cohort; hospital admissions

Subject

Medicine and Pharmacology, Cardiac and Cardiovascular Systems

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Download PDF Download Supplementary

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our Diversity statement.

Leave a public comment
Send a private comment to the author(s)
* All users must log in before leaving a comment
Views 0
Downloads 0
Comments 0
Metrics 0
Get PDF Supplementary Files Cite Share 0
Bookmark BibSonomy Mendeley Reddit Delicious
×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.