Preprint Communication Version 1 Preserved in Portico This version is not peer-reviewed

Disappearance of Temporal Collinearity in Vertebrates and its Eventual Reappearance

Version 1 : Received: 7 September 2021 / Approved: 7 September 2021 / Online: 7 September 2021 (09:56:27 CEST)

A peer-reviewed article of this Preprint also exists.

Papageorgiou, S. Disappearance of Temporal Collinearity in Vertebrates and Its Eventual Reappearance. Biology 2021, 10, 1018. Papageorgiou, S. Disappearance of Temporal Collinearity in Vertebrates and Its Eventual Reappearance. Biology 2021, 10, 1018.

Journal reference: Biology 2021, 10, 1018
DOI: 10.3390/biology10101018

Abstract

It was observed that a cluster of ordered genes (Hox1, Hox2, Hox3,…) in the genome are activated in the ontogenetic units (1, 2, 3,…) of an embryo along the Anterior/Posterior axis following the same order of the Hox genes. This Spatial Collinearity (SC) is very strange since it correlates events of very different spatial dimensions. It was later observed in vertebrates, that, in the above ordering, first is Hox1expressed in ontogenetic unit 1, followed later by Hox2 in unit 2, and even later Hox3 in unit 3….This temporal collinearity (TC) is an enigma and even to-day is explored in depth. In 1999 T. Kondo and D. Duboule, after posterior upstream extended DNA excisions , concluded that the Hox cluster behaves ‘as if’ TC disappears. Here the consideration of TC really disappearing is taken face value and its repercussions are analyzed. Furthermore, an experiment is proposed to test TC disappearance. An outcome of this experiment could be the reappearance (partial or total) of TC.

Keywords

HOX gene collinearity; spatial collinearity; temporal collinearity; TC disappearence; TC reappearence

Subject

LIFE SCIENCES, Genetics

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