Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Potential Nociceptive Role of the Thoracolumbar Fascia: A Scope Review Involving in Vivo and Ex Vivo Studies

Version 1 : Received: 16 August 2021 / Approved: 17 August 2021 / Online: 17 August 2021 (08:31:33 CEST)

A peer-reviewed article of this Preprint also exists.

Sinhorim, L.; Amorim, M.S.; Ortiz, M.E.; Bittencourt, E.B.; Bianco, G.; da Silva, F.C.; Horewicz, V.V.; Schleip, R.; Reed, W.R.; Mazzardo-Martins, L.; Martins, D.F. Potential Nociceptive Role of the Thoracolumbar Fascia: A Scope Review Involving In Vivo and Ex Vivo Studies. J. Clin. Med. 2021, 10, 4342. Sinhorim, L.; Amorim, M.S.; Ortiz, M.E.; Bittencourt, E.B.; Bianco, G.; da Silva, F.C.; Horewicz, V.V.; Schleip, R.; Reed, W.R.; Mazzardo-Martins, L.; Martins, D.F. Potential Nociceptive Role of the Thoracolumbar Fascia: A Scope Review Involving In Vivo and Ex Vivo Studies. J. Clin. Med. 2021, 10, 4342.

Journal reference: J. Clin. Med. 2021, 10, 4342
DOI: 10.3390/jcm10194342

Abstract

Nociceptive innervation of the thoracolumbar fascia (TLF) has been investigated over decades, however these studies have not been compiled or collectively appraised. The purpose of this scoping review was to assess current knowledge regarding nociceptive innervation of the TLF to better inform future mechanistic and clinical TLF research targeting low back pain (LBP) treatment. PubMed, ScienceDirect, Cochrane and Embase databases were searched in January 2021 using relevant descriptors encompassing fascia and pain. Eligible studies were: (a) published in English; (b) preclinical and clinical (in vivo and ex vivo) studies; (c) original data; (d) included quantification of at least one TLF nociceptive component. Two-phase screening procedures were conducted by a pair of independent reviewers, data were extracted and summarized from eligible studies. The search resulted in 257 articles of which 10 met inclusion criteria. Studies showed histological evidence of nociceptive nerve fibers terminating in low back fascia, suggesting a TLF contribution to LBP. Noxious chemical injection or electrical stimulation into fascia resulted in longer pain duration and higher pain intensities than injections into subcutaneous tissue or muscle. Pre-clinical and clinical research provides histological and functional evidence of nociceptive innervation of TLF. Greater knowledge of fascial neurological components could impact LBP treatment.

Keywords

fascia; in vivo; ex vivo; innervation; pain; thoracolumbar fascia; nociceptor; low back pain; scoping review.

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