Direct Use of Clinical Tolerance Limits for Assessing Agreement: A Robust Nonparametric Approach

Abhaya Indrayan

doi:10.20944/preprints202108.0343.v1

Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Version 1 : Received: 15 August 2021 / Approved: 16 August 2021 / Online: 16 August 2021 (13:53:22 CEST)

Clinical agreement between two quantitative measurements on a group of subjects is generally assessed with the help of the Bland-Altman (B-A) limits. The interpretation regarding agreement is based on whether B-A limits are within the pre-specified clinical tolerance. Thus, clinical tolerance limits are necessary for this method. We argue in this communication that such limits of clinical tolerance can be directly used for assessing agreement and plead that this nonparametric approach is simple and robust to the distribution pattern and outliers. Such direct use of clinical tolerance limits has more flexibility, and it is more effective in assessing the extent of agreement.

Agreement analysis; Bland-Altman method; Clinical tolerance limits; Limits of agreement; Nonparametric approach; Robust method

Medicine and Pharmacology, Clinical Medicine

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Direct Use of Clinical Tolerance Limits for Assessing Agreement: A Robust Nonparametric Approach

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