Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Facile Synthesis of Sulfonyl Chlorides/Bromides from Sulfonyl Hydrazides

Version 1 : Received: 13 August 2021 / Approved: 16 August 2021 / Online: 16 August 2021 (13:31:28 CEST)

A peer-reviewed article of this Preprint also exists.

Chen, R.; Xu, S.; Shen, F.; Xu, C.; Wang, K.; Wang, Z.; Liu, L. Facile Synthesis of Sulfonyl Chlorides/Bromides from Sulfonyl Hydrazides. Molecules 2021, 26, 5551. Chen, R.; Xu, S.; Shen, F.; Xu, C.; Wang, K.; Wang, Z.; Liu, L. Facile Synthesis of Sulfonyl Chlorides/Bromides from Sulfonyl Hydrazides. Molecules 2021, 26, 5551.

Journal reference: Molecules 2021, 26, 5551
DOI: 10.3390/molecules26185551

Abstract

A simple and rapid method for efficient synthesis of sulfonyl chlorides/bromides from sulfonyl hydrazide with NXS (X = Cl or Br) and late-stage conversion to several other functional groups has been described. A variety of nucleophiles could be engaged in this transformation thus permitting the synthesis of complex sulfonamides, sulfonates. In most cases, these reactions are highly selective, simple, and clean, affording products in excellent yields.

Keywords

Sulfonyl chlorides; sulfonyl bromides; sulfonyl hydrazides; NCS; NBS

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