Chen, R.; Xu, S.; Shen, F.; Xu, C.; Wang, K.; Wang, Z.; Liu, L. Facile Synthesis of Sulfonyl Chlorides/Bromides from Sulfonyl Hydrazides. Molecules2021, 26, 5551.
Chen, R.; Xu, S.; Shen, F.; Xu, C.; Wang, K.; Wang, Z.; Liu, L. Facile Synthesis of Sulfonyl Chlorides/Bromides from Sulfonyl Hydrazides. Molecules 2021, 26, 5551.
Chen, R.; Xu, S.; Shen, F.; Xu, C.; Wang, K.; Wang, Z.; Liu, L. Facile Synthesis of Sulfonyl Chlorides/Bromides from Sulfonyl Hydrazides. Molecules2021, 26, 5551.
Chen, R.; Xu, S.; Shen, F.; Xu, C.; Wang, K.; Wang, Z.; Liu, L. Facile Synthesis of Sulfonyl Chlorides/Bromides from Sulfonyl Hydrazides. Molecules 2021, 26, 5551.
Abstract
A simple and rapid method for efficient synthesis of sulfonyl chlorides/bromides from sulfonyl hydrazide with NXS (X = Cl or Br) and late-stage conversion to several other functional groups has been described. A variety of nucleophiles could be engaged in this transformation thus permitting the synthesis of complex sulfonamides, sulfonates. In most cases, these reactions are highly selective, simple, and clean, affording products in excellent yields.
Chemistry and Materials Science, Organic Chemistry
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