Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Spectral Optical Properties of Rabbit Brain Cortex Between 200 and 1000 nm

Version 1 : Received: 25 June 2021 / Approved: 29 June 2021 / Online: 29 June 2021 (12:57:34 CEST)

How to cite: Gonçalves, T.; Martins, I.S.; Silva, H.; Tuchin, V.; Oliveira, L. Spectral Optical Properties of Rabbit Brain Cortex Between 200 and 1000 nm. Preprints 2021, 2021060707 (doi: 10.20944/preprints202106.0707.v1). Gonçalves, T.; Martins, I.S.; Silva, H.; Tuchin, V.; Oliveira, L. Spectral Optical Properties of Rabbit Brain Cortex Between 200 and 1000 nm. Preprints 2021, 2021060707 (doi: 10.20944/preprints202106.0707.v1).

Abstract

The knowledge of the optical properties of biological tissues in a wide spectral range is highly important for the development of noninvasive diagnostic or treatment procedures. The absorption coefficient is one of those properties, from which various information about tissue components can be retrieved. Using transmittance and reflectance spectral measurements acquired from ex vivo rabbit brain cortex samples, allowed to calculate its optical properties in the ultraviolet to the near infrared spectral range. Melanin and lipofuscin, the two pigments that are related to the ageing of tissues and cells were identified in the cortex absorption. By subtracting the absorption of these pigments from the absorption of the brain cortex, it was possible to evaluate the true ratios for the DNA/RNA and hemoglobin bands in the cortex – 12.33 fold (at 260 nm), 12.02 fold (at 411 nm) and 4.47 fold (at 555 nm). Due to the fact that the accumulation of melanin and lipofuscin increases with the ageing of the brain tissues and are related to the degeneration of neurons and their death, further studies should be performed to evaluate the evolution of pigment accumulation in the brain to prevent the development of Alzheimer, Parkinson and stroke pathologies in the brain.

Subject Areas

tissue spectroscopy; tissue optical properties; scattering coefficient; absorption coefficient; DNA content; blood content; pigment detection

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