Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Cannabidiol Modulates the Motivational and Anxiety-Like Effects of 3,4-Methylenedioxypyrovalerone (MDPV) in Mice

Version 1 : Received: 25 June 2021 / Approved: 28 June 2021 / Online: 28 June 2021 (11:35:52 CEST)

A peer-reviewed article of this Preprint also exists.

Alegre-Zurano, L.; López-Arnau, R.; Luján, M.Á.; Camarasa, J.; Valverde, O. Cannabidiol Modulates the Motivational and Anxiety-Like Effects of 3,4-Methylenedioxypyrovalerone (MDPV) in Mice. Int. J. Mol. Sci. 2021, 22, 8304. Alegre-Zurano, L.; López-Arnau, R.; Luján, M.Á.; Camarasa, J.; Valverde, O. Cannabidiol Modulates the Motivational and Anxiety-Like Effects of 3,4-Methylenedioxypyrovalerone (MDPV) in Mice. Int. J. Mol. Sci. 2021, 22, 8304.

Journal reference: Int. J. Mol. Sci. 2021, 22, 8304
DOI: 10.3390/ijms22158304

Abstract

3,4-methylenedioxypyrovalerone (MDPV) is a new psychoactive substance (NPS) and the most widespread and life-threatening synthetic cathinone of the “bath salts”. Preclinical research has proven the cocaine-like psychostimulant effects of MDPV and its potential for abuse. Cannabidiol (CBD) is a non-psychotropic phytocannabinoid that has emerged as a new potential treatment for drug addiction. Here, we tested the effects of CBD (20 mg/kg) on MDPV (2 mg/kg)-induced conditioned place preference and MDPV (0.05 and 0.075 mg/kg/infusion) self-administration paradigm. We also assessed the effects of the combination of CBD, and MDPV (3 and 4 mg/kg) on anxiety-like behaviour using the elevated plus maze (EPM). CBD mitigated the MDPV-induced conditioned place preference. On the contrary, CBD administration throughout the MDPV (0.075 mg/kg/infusion) self-administration increased drug-seeking and taking behaviours, but only in the high-responders group of mice. Additionally, CBD exerted anxiolytic-like effects, but only in MDPV-treated mice. Taken together, our results indicate that CBD modulation of MDPV-induced motivational responses in mice vary depending on the requirements of the learning task, resulting in a complex response. More research attempting to decipher the behavioural and molecular interactions between CBD and MDPV is needed.

Keywords

MDPV; cannabidiol; conditioned place preference; self-administration; anxiety; mice

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