Working Paper Article Version 1 This version is not peer-reviewed

Preparation of Galangin Self-microemulsion Drug Delivery System and Evaluation of Its Pharmacokinetics In Vivo and Antioxidant Activity In Vitro

Version 1 : Received: 11 June 2021 / Approved: 15 June 2021 / Online: 15 June 2021 (15:30:12 CEST)

How to cite: Lu, H.; Chen, X.; Xu, H. Preparation of Galangin Self-microemulsion Drug Delivery System and Evaluation of Its Pharmacokinetics In Vivo and Antioxidant Activity In Vitro. Preprints 2021, 2021060414 Lu, H.; Chen, X.; Xu, H. Preparation of Galangin Self-microemulsion Drug Delivery System and Evaluation of Its Pharmacokinetics In Vivo and Antioxidant Activity In Vitro. Preprints 2021, 2021060414

Abstract

Galangin(Gal) is a natural active flavonoid compound separated from the roots and rhizomes of Alpinia ofcinarum Hance. Modern pharmacological studies have shown that Gal has a variety of biological activities such as anti-tumor, anti-fungal, anti-bacterial, anti-inflammatory, anti-ischemic stroke, suppressing vitiligo and Alzheimer’s disease, etc. The purpose of this research was to prepare a galangin self-microemulsion drug delivery system (Gal-SMEDDS) and compare its anti-oxidant activity and pharmacokinetics with free Gal.The average particle size of the prepared Gal-SMEDDS was approximately 21.33 nm, the polydispersity index was 0.096, the zeta potential was -4.09 mV, and the entrapment efficiency was 96.74%. Compared with free Gal, the release of Gal-SMEDDS was improved in vitro release experiment. Cell experiments showed that Gal had obvious anti-oxidation effect, and the effect of Gal-SMEDDS was better than that of free Gal. In vivo pharmacokinetic experiments showed that the pharmacokinetic parameters of Gal-SMEDDS were better than that of free Gal, which indicated that the self-microemulsion drug delivery system(SMEDDS) effectively increases the oral bioavailability of Gal and alters its pharmacokinetic parameters, such that it may be effective in the treatment of anti-oxidant.

Keywords

galangin; Self microemulsion drug delivery system; Antioxidant damage; Pharmacokinetics

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