Preprint Communication Version 1 Preserved in Portico This version is not peer-reviewed

Role of N501Y Mutation in SARS-CoV-2 Spike Protein Structure

Version 1 : Received: 8 June 2021 / Approved: 8 June 2021 / Online: 8 June 2021 (13:57:03 CEST)

How to cite: Roy, U. Role of N501Y Mutation in SARS-CoV-2 Spike Protein Structure. Preprints 2021, 2021060238 (doi: 10.20944/preprints202106.0238.v1). Roy, U. Role of N501Y Mutation in SARS-CoV-2 Spike Protein Structure. Preprints 2021, 2021060238 (doi: 10.20944/preprints202106.0238.v1).

Abstract

It has been more than a year since the first case of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was found. This coronavirus has infected more than 110 million people worldwide by the end of February, 2021, and several virulent as well as more spreadable mutant forms of SARS-CoV-2 have emerged subsequently. In the latter group, three variants B.1.1.7, B.1.351, and P1 lineages, have been reported. Using computer simulation, the present paper investigates the structural differences between the wild type SARS-CoV-2 spike protein and its Asn501Tyr (N501Y) mutant variant. Time-based structural changes between the receptor binding domains of these two species are also examined. The N501Y mutation is common to all the three aforesaid mutant variants.

Subject Areas

Immunoinformatics; Molecular dynamics simulation; mutation; SARS-CoV-2; Spike protein; Virus structure

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