Preprint Short Note Version 1 Preserved in Portico This version is not peer-reviewed

SARS-CoV-2 Origin: An Affair of Codons?

Version 1 : Received: 2 June 2021 / Approved: 4 June 2021 / Online: 4 June 2021 (08:00:03 CEST)

How to cite: Romeu, A.R.; Ollé, E. SARS-CoV-2 Origin: An Affair of Codons?. Preprints 2021, 2021060121 (doi: 10.20944/preprints202106.0121.v1). Romeu, A.R.; Ollé, E. SARS-CoV-2 Origin: An Affair of Codons?. Preprints 2021, 2021060121 (doi: 10.20944/preprints202106.0121.v1).

Abstract

The furin cleavage site, with an arginine doublet (RR), is one of the clues of the SARS-CoV-2 origin. This furin-RR is encoded by the CGG-CGG sequence. Because arginine can be encoded by six codons, in a previous work we found that in SARS-CoV-2, CGG was the minority arginine codon (3%). Also, analyzing the RR doublet from a large sample of furin cleavage sites of several kinds of viruses, we found that none of them were encoded by CGG-CGG. Here, we come back to the core of the matter, but from the perspective that in the human genome, in contrast, CGG is the majoroty arginine codon (21%). Here, we highlighted that the 6 arginine codons provide genetic markers to a traceability on the RR origin in the furin site, as well as, to weigh the probability of the theories about the origin of the virus.

Subject Areas

SARS-CoV-2 origin; Furin Cleavage Site; Arginine Codon Usage; Bioinformatics

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