Preprint Review Version 2 Preserved in Portico This version is not peer-reviewed

Systematic Review of Centrifugal Valving Based on Digital Twin Modelling towards Highly Integrated Lab-on-a-Disc Systems

Version 1 : Received: 26 May 2021 / Approved: 27 May 2021 / Online: 27 May 2021 (15:06:56 CEST)
Version 2 : Received: 7 June 2021 / Approved: 7 June 2021 / Online: 7 June 2021 (14:45:53 CEST)

A peer-reviewed article of this Preprint also exists.

Journal reference: Applied Sciences 2021, 11, 5839
DOI: 10.3390/app11135839


Current, application-driven trends towards larger-scale integration (LSI) of microfluidic systems for comprehensive assay automation and multiplexing pose significant technological and economical challenges to developers. By virtue of their intrinsic capability for powerful sample preparation, centrifugal systems have attracted significant interest in academia and business since the early 1990s. This review models common, rotationally controlled valving schemes at the heart of such “Lab-on-a-Disc” (LoaD) platforms to predict critical spin rates and reliability of flow control mainly based on geometries, location and liquid volumes to be processed, and their experimental tolerances. In absence of larger-scale manufacturing facilities during product development, the method presented here facilitates the provision of efficient simulation tools for virtual prototyping and characterization to greatly expedite design optimization according to key performance metrics. This virtual in silico approach thus significantly accelerates, de-risks and lowers costs along the critical advancement from idea, fluidic testing, bioanalytical validation and scale-up to commercial mass manufacture.


centrifugal microfluidics; Lab-on-a-Disc; fluidic integration; rotational flow control; valving


ENGINEERING, Biomedical & Chemical Engineering

Comments (1)

Comment 1
Received: 7 June 2021
Commenter: Jens Ducrée
Commenter's Conflict of Interests: Author
Comment: Updates and edits requested by referees
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