Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

De-Coding the Contributions of the Viral RNAs to Alphaviral Pathogenesis

Version 1 : Received: 11 May 2021 / Approved: 16 May 2021 / Online: 16 May 2021 (22:27:20 CEST)

A peer-reviewed article of this Preprint also exists.

LaPointe, A.T.; Sokoloski, K.J. De-Coding the Contributions of the Viral RNAs to Alphaviral Pathogenesis. Pathogens 2021, 10, 771. LaPointe, A.T.; Sokoloski, K.J. De-Coding the Contributions of the Viral RNAs to Alphaviral Pathogenesis. Pathogens 2021, 10, 771.

Journal reference: Pathogens 2021, 10, 771
DOI: 10.3390/pathogens10060771

Abstract

Alphaviruses are positive-sense RNA arboviruses that are capable of causing severe disease in otherwise healthy individuals. There are many aspects of viral infection that determine pathogenesis and major efforts regarding the identification and characterization of virulence determinants have largely focused on the roles of the nonstructural and structural proteins. Nonetheless, the viral RNAs of the alphaviruses themselves play important roles in regard to virulence and pathogenesis. In particular, many sequences and secondary structures within the viral RNAs play an important part in the development of disease and may be considered important determinants of virulence. In this review article, we summarize the known RNA-based virulence traits and host:RNA interactions that influence alphaviral pathogenesis for each of the viral RNA species produced during infection. Overall, the viral RNAs produced during infection are important contributors to alphaviral pathogenesis and more research is needed to fully understand how each RNA species impacts the host response to infection as well as the development of disease.

Subject Areas

Alphavirus; Virulence; Viral Pathogenesis; Viral RNA

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