Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Risk Factors for Recurrent Aphthous Stomatitis: A Systematic Review

Version 1 : Received: 8 May 2021 / Approved: 10 May 2021 / Online: 10 May 2021 (13:55:48 CEST)

A peer-reviewed article of this Preprint also exists.

Rivera C, Muñoz A, Puentes C, Aguayo E. Risk factors for recurrent aphthous stomatitis: a systematic review. Int J Morphol. 2021;39(4):1102-8. doi: 10.4067/S0717-95022021000401102 Rivera C, Muñoz A, Puentes C, Aguayo E. Risk factors for recurrent aphthous stomatitis: a systematic review. Int J Morphol. 2021;39(4):1102-8. doi: 10.4067/S0717-95022021000401102

Journal reference: Int J Morphol 2021, 39, 1102-1108
DOI: 10.4067/S0717-95022021000401102

Abstract

The cause and prevention of recurrent aphthous stomatitis (also called aphthous ulcers or canker sores) are still unknown. This may be due in part to ignorance of the risk factors present in susceptible people. In this systematic review (PROSPERO record #CRD42019122214), we show that most of the risk factors for the disease are single nucleotide genetic polymorphisms in genes related to the functioning of immune system (TLR4, MMP9, E-selectin, IL-1 beta and TNF-alpha). Single nucleotide genetic polymorphisms do not constitute a modifiable risk. This indicates that, at least in part, susceptibility to recurrent aphthous stomatitis is hereditary, and that these factors cannot be modified.

Supplementary and Associated Material

Keywords

aphthous stomatitis, risk factors, genetic polymorphisms, multivariate analysis, systematic review

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