Risk Factors for Recurrent Aphthous Stomatitis: A Systematic Review

César Rivera; Antonieta Muñoz; Carolina Puentes; Esteban Aguayo

doi:10.20944/preprints202105.0194.v1

Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Version 1 : Received: 8 May 2021 / Approved: 10 May 2021 / Online: 10 May 2021 (13:55:48 CEST)

The cause and prevention of recurrent aphthous stomatitis (also called aphthous ulcers or canker sores) are still unknown. This may be due in part to ignorance of the risk factors present in susceptible people. In this systematic review (PROSPERO record #CRD42019122214), we show that most of the risk factors for the disease are single nucleotide genetic polymorphisms in genes related to the functioning of immune system (TLR4, MMP9, E-selectin, IL-1 beta and TNF-alpha). Single nucleotide genetic polymorphisms do not constitute a modifiable risk. This indicates that, at least in part, susceptibility to recurrent aphthous stomatitis is hereditary, and that these factors cannot be modified.

aphthous stomatitis, risk factors, genetic polymorphisms, multivariate analysis, systematic review

Medicine and Pharmacology, Immunology and Allergy

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Risk Factors for Recurrent Aphthous Stomatitis: A Systematic Review

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