Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Thermogenic Fat: Development, Physiological Function, and Therapeutic Potential

Version 1 : Received: 30 April 2021 / Approved: 3 May 2021 / Online: 3 May 2021 (15:58:01 CEST)

A peer-reviewed article of this Preprint also exists.

Brandão, B.B.; Poojari, A.; Rabiee, A. Thermogenic Fat: Development, Physiological Function, and Therapeutic Potential. Int. J. Mol. Sci. 2021, 22, 5906. Brandão, B.B.; Poojari, A.; Rabiee, A. Thermogenic Fat: Development, Physiological Function, and Therapeutic Potential. Int. J. Mol. Sci. 2021, 22, 5906.

Journal reference: Int. J. Mol. Sci. 2021, 22, 5906
DOI: 10.3390/ijms22115906

Abstract

The concerning worldwide increase of obesity and chronic metabolic diseases such as T2D, dyslipidemia, and cardiovascular disease motivates further investigations into preventive and alternative therapeutic approaches. Over the past decade, there is growing evidence that the formation and activation of thermogenic adipocytes (brown and beige) may serve as therapy to treat obesity and its associated diseases owing to its capacity to increase energy expenditure and to modulate circulating lipids and glucose levels. Thus, understanding the molecular mechanism of brown and beige adipocytes formation and activation will facilitate the development of strategies to combat metabolic disorders. Here, we provide a comprehensive overview of pathways and players involved in the development of brown and beige fat as well as the role of thermogenic adipocytes in energy homeostasis and metabolism. Also, we discuss the alterations in brown and beige adipose tissue function during obesity and, explore the therapeutic potential of thermogenic activation to treat metabolic syndrome.

Subject Areas

Adipose Tissue, Development, Molecular Circuits, Secretome, Thermogenesis, Metabolism, Obesity, Therapy

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