Preprint Article Version 1 This version is not peer-reviewed

Association Between Transcription Factor 7-Like-2 Polymorphisms and Type 2 Diabetes Mellitus in a Ghanaian Population

Version 1 : Received: 23 April 2021 / Approved: 26 April 2021 / Online: 26 April 2021 (10:41:30 CEST)

How to cite: Obirikorang, C.; Adu, E.A.; Odame, E.O.; Acheampong, E.; Quaye, L.; Yeboah Amoah, B.; Annani-Akollor, M.E.; Siaw. Kwakye, A.; Fokuoh, F.; Appiah, M.; Nyarko, E.N.Y.; Aidoo, F.; Adua, E.; AFRIFA-YAMOAH, E.; Balmer, L.; Wang, W. Association Between Transcription Factor 7-Like-2 Polymorphisms and Type 2 Diabetes Mellitus in a Ghanaian Population. Preprints 2021, 2021040650 (doi: 10.20944/preprints202104.0650.v1). Obirikorang, C.; Adu, E.A.; Odame, E.O.; Acheampong, E.; Quaye, L.; Yeboah Amoah, B.; Annani-Akollor, M.E.; Siaw. Kwakye, A.; Fokuoh, F.; Appiah, M.; Nyarko, E.N.Y.; Aidoo, F.; Adua, E.; AFRIFA-YAMOAH, E.; Balmer, L.; Wang, W. Association Between Transcription Factor 7-Like-2 Polymorphisms and Type 2 Diabetes Mellitus in a Ghanaian Population. Preprints 2021, 2021040650 (doi: 10.20944/preprints202104.0650.v1).

Abstract

Type-2 diabetes mellitus (T2DM) have been strongly associated with single nucleotide polymorphisms (SNPs) in the TCF7L2 gene. This study investigated the association between rs12255372, rs7903146 and T2DM in a Ghanaian population. A case-control study design was used for this study. A total of 106 T2DM patients and 110 control participants were selected. Basic data collected included body mass index, blood pressure and socio-demographics. Fasting blood samples were collected and used for serum lipid analysis, HbA1c, plasma glucose estimation and DNA extraction. Common and allele-specific primers were designed for genotyping using the Modified Tetra-Primer Amplification assay. Associations were evaluated using logistic regression models. The rs7903146 risk variant was significantly associated with 2.16 vs 4.06 increased odds for T2DM in patients <60 years vs ≥60 years. Both rs7903146 and rs12255372 are significantly associated with increased odds of T2DM in women, overweight/obese; T2DM negative family history (T2DM-NFH) and low-HDL-C. In a multivariate model, rs7903146 but not rs12255372 was significantly associated with 2.18, 5.01 and 2.25 increased odds of T2DM, under the codominant, recessive and additive model, respectively (p<0.05). The association between rs7903146 and rs12255372 with T2DM is more highly associated in a subgroup- women and those with T2DM-NFH, yet have cardiometabolic risk.

Subject Areas

TCF7L2, type 2 diabetes mellitus, cardiometabolic risk factors, single nucleotide polymorphisms

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