Article
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Preserved in Portico This version is not peer-reviewed
Modeling Retinal Ganglion Cell Dysfunction in Optic Neuropathies
Version 1
: Received: 19 April 2021 / Approved: 21 April 2021 / Online: 21 April 2021 (11:38:10 CEST)
A peer-reviewed article of this Preprint also exists.
Porciatti, V.; Chou, T.-H. Modeling Retinal Ganglion Cell Dysfunction in Optic Neuropathies. Cells 2021, 10, 1398. Porciatti, V.; Chou, T.-H. Modeling Retinal Ganglion Cell Dysfunction in Optic Neuropathies. Cells 2021, 10, 1398.
Abstract
As in glaucoma and other optic neuropathies cellular dysfunction often precedes cell death, sensitive assessment of retinal ganglion cell (RGC) function represents a key outcome measure for neuroprotective strategies aimed at targeting distressed but still viable cells. Here we offer a conceptual framework to identify progressive stages of RGC dysfunction leading to cell death in mouse models of glaucoma and other optic neuropathies based on non-invasive pattern electroretinogram (PERG), to differentiate phenotypic and altered RGC response dynamics, to assess susceptibility to stressors and to assess reversible dysfunction.
Keywords
Retinal ganglion cell function; Pattern electroretinogram; Glaucoma; Optic neuropathy
Subject
Medicine and Pharmacology, Immunology and Allergy
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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