Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Modeling Retinal Ganglion Cell Dysfunction in Optic Neuropathies

Version 1 : Received: 19 April 2021 / Approved: 21 April 2021 / Online: 21 April 2021 (11:38:10 CEST)

A peer-reviewed article of this Preprint also exists.

Porciatti, V.; Chou, T.-H. Modeling Retinal Ganglion Cell Dysfunction in Optic Neuropathies. Cells 2021, 10, 1398. Porciatti, V.; Chou, T.-H. Modeling Retinal Ganglion Cell Dysfunction in Optic Neuropathies. Cells 2021, 10, 1398.

Journal reference: Cells 2021, 10, 1398
DOI: 10.3390/cells10061398

Abstract

As in glaucoma and other optic neuropathies cellular dysfunction often precedes cell death, sensitive assessment of retinal ganglion cell (RGC) function represents a key outcome measure for neuroprotective strategies aimed at targeting distressed but still viable cells. Here we offer a conceptual framework to identify progressive stages of RGC dysfunction leading to cell death in mouse models of glaucoma and other optic neuropathies based on non-invasive pattern electroretinogram (PERG), to differentiate phenotypic and altered RGC response dynamics, to assess susceptibility to stressors and to assess reversible dysfunction.

Keywords

Retinal ganglion cell function; Pattern electroretinogram; Glaucoma; Optic neuropathy

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