Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Concurrent Heavy Metal Exposures and Idiopathic Dilated Cardiomyopathy: A Case-Control Study From the Katanga Mining Area of the Democratic Republic of Congo

Didier Malamba-Lez
* ORCID logo ,
Désiré Tshala-Katumbay
,
Virginie Bito
,
Jean-Michel RIGO
,
Richie Kipenge Kyandabike
ORCID logo ,
Eric Ngoy Yolola
,
Philippe Katchunga
,
Béatrice Koba-Bora
,
Dophra Ngoy-Nkulu
Version 1 : Received: 15 April 2021 / Approved: 16 April 2021 / Online: 16 April 2021 (10:43:32 CEST)

A peer-reviewed article of this Preprint also exists.

Malamba-Lez, D.; Tshala-Katumbay, D.; Bito, V.; Rigo, J.-M.; Kyandabike, R.K.; Yolola, E.N.; Katchunga, P.; Koba-Bora, B.; Ngoy-Nkulu, D. Concurrent Heavy Metal Exposures and Idiopathic Dilated |Cardiomyopathy: A Case-Control Study from the Katanga Mining Area of the Democratic Republic of Congo. Int. J. Environ. Res. Public Health 2021, 18, 4956. Malamba-Lez, D.; Tshala-Katumbay, D.; Bito, V.; Rigo, J.-M.; Kyandabike, R.K.; Yolola, E.N.; Katchunga, P.; Koba-Bora, B.; Ngoy-Nkulu, D. Concurrent Heavy Metal Exposures and Idiopathic Dilated |Cardiomyopathy: A Case-Control Study from the Katanga Mining Area of the Democratic Republic of Congo. Int. J. Environ. Res. Public Health 2021, 18, 4956.

Abstract

Blood and/or urine levels of 27 heavy metals were determined by ICPMS in 41 patients with dilated cardiomyopathy (DCM) and 29 presumably healthy subjects from the Katanga Copperbelt (KC), in the Democratic Republic of Congo (DRC). After adjusting for age, gender, education level, and renal function, DCM probability was almost maximal for blood concentrations above 0.75 and 150 µg/dl for arsenic and copper, respectively. Urinary concentrations above 1 for chromium, 20 for copper, 600 for zinc, 30 for selenium, 2 for cadmium, 0.2 for antimony, 0.5 for thallium and 0.05 for uranium, all in μg/g of creatinine, were also associated with increased DCM probability. Concurrent and multiple exposures to heavy metals, well beyond permissible levels, are associated with increased probability for DCM. Study findings warrant screening for metal toxicity in case of DCM and prompt public health measures to reduce exposures in the KC, DRC.

Keywords

environmental exposures; heavy metals; idiopathic dilated cardiomyopathy; Katanga Copperbelt

Subject

Medicine and Pharmacology, Immunology and Allergy

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Download PDF Download Supplementary

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our Diversity statement.

Leave a public comment
Send a private comment to the author(s)
* All users must log in before leaving a comment
Views 0
Downloads 0
Comments 0
Metrics 0
Get PDF Supplementary Files Cite Share 0
Bookmark BibSonomy Mendeley Reddit Delicious
×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.