Preprint Communication Version 1 Preserved in Portico This version is not peer-reviewed

An Orally Bioavailable (Mice) Prodrug of Glutathione

Version 1 : Received: 13 April 2021 / Approved: 14 April 2021 / Online: 14 April 2021 (11:40:14 CEST)

How to cite: Nagasawa, H.T.; Crankshaw, D.L.; Briggs, J.E.; Vince, R. An Orally Bioavailable (Mice) Prodrug of Glutathione. Preprints 2021, 2021040368 (doi: 10.20944/preprints202104.0368.v1). Nagasawa, H.T.; Crankshaw, D.L.; Briggs, J.E.; Vince, R. An Orally Bioavailable (Mice) Prodrug of Glutathione. Preprints 2021, 2021040368 (doi: 10.20944/preprints202104.0368.v1).

Abstract

Cysteine-glutathione mixed disulfide (CySSG), a prodrug of glutathione (GSH) --the “Master Antioxidant”, was found to be orally bioavailable in mice, and protected against a toxic dose of acetaminophen. If oral bioavailability can also be demonstrated in humans, this suggests a wide range of applicability for CySSG.

Subject Areas

CySSG; prodrug; glutathione; orally; bioavailable

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