Working Paper Hypothesis Version 1 This version is not peer-reviewed

Autoimmune Thrombotic Thrombocytopathy Associated with COVID-19 Infection or Vaccination: Learning from Heparin-induced Thrombocytopenia

Version 1 : Received: 8 April 2021 / Approved: 9 April 2021 / Online: 9 April 2021 (10:13:14 CEST)
Version 2 : Received: 15 April 2021 / Approved: 15 April 2021 / Online: 15 April 2021 (14:05:48 CEST)

How to cite: Goldman, M. Autoimmune Thrombotic Thrombocytopathy Associated with COVID-19 Infection or Vaccination: Learning from Heparin-induced Thrombocytopenia. Preprints 2021, 2021040255 Goldman, M. Autoimmune Thrombotic Thrombocytopathy Associated with COVID-19 Infection or Vaccination: Learning from Heparin-induced Thrombocytopenia. Preprints 2021, 2021040255

Abstract

Prothrombotic thrombocytopathy mimicking heparin-induced thrombocytopenia has been observed in patients with severe COVID-19 and after immunisation with the Vaxzevria vaccine. Herein, we discuss the possible pathogenesis of this disorder focusing on the possible involvement of anti-platelet factor 4 (PFA) autoantibodies.

Keywords

COVID-19; vaccine; heparin; thrombocytopenia; thrombosis; platelet; endothelial cell; autoimmunity; proteoglycan; B cell; coagulation

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