Review
Version 1
Preserved in Portico This version is not peer-reviewed
Role of Citicoline in the Management of Traumatic Brain Injury
Version 1
: Received: 30 March 2021 / Approved: 31 March 2021 / Online: 31 March 2021 (14:42:27 CEST)
A peer-reviewed article of this Preprint also exists.
Secades, J.J. Role of Citicoline in the Management of Traumatic Brain Injury. Pharmaceuticals 2021, 14, 410. Secades, J.J. Role of Citicoline in the Management of Traumatic Brain Injury. Pharmaceuticals 2021, 14, 410.
Abstract
Head injury is among the most devastating types of injury, specifically called Traumatic Brain Injury (TBI). There is need to diminish the morbidity related with TBI and to improve the outcome of patients suffering TBI. Among the improvements on the treatment of TBI, neuroprotection is one of the upcoming improvements. Citicoline has been used in the management of brain ischemia related disorders, such as TBI. Citicoline has biochemical, pharmacological, and pharmacokinetic characteristics that make it a potentially useful neuroprotective drug for the management of TBI. A short review of these characteristics is included in this paper. Also, a narrative review of almost all the published or communicated studies performed with this drug in the management of patients with head injury is included. Based on the results obtained in these clinical studies, it is possible to conclude that citicoline was able to accelerate recovery of consciousness and to improve the outcome of this kind of patients, with an excellent safety profile. Thus, citicoline could have a potential role in the management of TBI.
Keywords
CDP-choline; citicoline; pharmacological neuroprotection; brain ischemia; traumatic brain injury; head injury
Subject
Medicine and Pharmacology, Immunology and Allergy
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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