Preprint Brief Report Version 1 Preserved in Portico This version is not peer-reviewed

Evolutionary Aspect of Miltefosine Transporter Proteins in Leishmania major

Version 1 : Received: 30 March 2021 / Approved: 31 March 2021 / Online: 31 March 2021 (09:55:35 CEST)

How to cite: Kabra, R.; Singh, S. Evolutionary Aspect of Miltefosine Transporter Proteins in Leishmania major. Preprints 2021, 2021030755 (doi: 10.20944/preprints202103.0755.v1). Kabra, R.; Singh, S. Evolutionary Aspect of Miltefosine Transporter Proteins in Leishmania major. Preprints 2021, 2021030755 (doi: 10.20944/preprints202103.0755.v1).

Abstract

Transporter proteins, P-glycoprotein (P-gp) and P4ATPase-CDC50, are responsible for the transport of Miltefosine drug across cell membrane of a protozoan parasite Leishmania major. Mutations or change in activity of these proteins may lead to emergence of resistance in the parasite. Owing to the structural and functional importance of these transporter proteins, in this ppaper, we have tried to decipher the evolutionary divergence of these Miltefosine transporter proteins across different forms of life including Protists, Fungi, Plants and Animals. We retrieved 96, 207, and 189 sequences of P-gp, P4ATPase and CDC50 proteins respectively, across diverse variety of organisms for the conserved analysis. Phylogenetic trees were constructed for these three transporter proteins based on Bayesian posterior probability inference. The evolutionary analysis concluded that these proteins remain highly conserved throughout the species diversity but still substantial differences in the proteins for host (Homo sapiens) and parasite (L. major) were observed which have led in targeting these Miltefosine transporter proteins in a parasite specific manner.

Keywords

evolutionary divergence; phylogenetic analysis; transporter proteins; Leishmania major

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