Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Living in the Endosymbiotic World of Wolbachia: A Centennial Review

Version 1 : Received: 10 March 2021 / Approved: 12 March 2021 / Online: 12 March 2021 (09:17:01 CET)

A peer-reviewed article of this Preprint also exists.

Journal reference: Cell Host & Microbe 2021
DOI: 10.1016/j.chom.2021.03.006

Abstract

The most widespread intracellular bacteria in the animal kingdom are maternally-inherited endosymbionts of the genus Wolbachia. Their prevalence in arthropods and nematodes worldwide and a stunning arsenal of parasitic and mutualistic adaptations make these bacteria a biological archetype for basic studies of symbiosis and applied outcomes for curbing human and agricultural diseases. Here, we conduct a summative, centennial analysis of living in the Wolbachia world. We synthesize literature on Wolbachia’s host range, phylogenetic diversity, genomics, cell biology, and applications to filarial, arboviral, and agricultural diseases. We also review the mobilome of Wolbachia including phage WO and its essentiality to hallmark phenotypes in arthropods. Finally, the Wolbachia system is an exemplar for discovery-based science education using biodiversity, biotechnology, and bioinformatics lessons. As we approach a century of Wolbachia research, applications, and education, the interdisciplinary science and knowledge from this symbiosis stand as a model for consolidating and teaching the integrative rules of endosymbiotic life.

Keywords

Wolbachia; phage WO; cytoplasmic incompatibility; male killing; feminization; parthenogenesis; evolution; vector control

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