Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

HLA Polymorphisms and Risk of Glioblastoma in Koreans

Version 1 : Received: 9 March 2021 / Approved: 10 March 2021 / Online: 10 March 2021 (13:09:25 CET)

How to cite: Ahn, S.; Choi, H.; Baek, I.; Park, S.A.; Kim, Y.S.; Park, J.; Kim, T.; Jeun, S. HLA Polymorphisms and Risk of Glioblastoma in Koreans. Preprints 2021, 2021030280 (doi: 10.20944/preprints202103.0280.v1). Ahn, S.; Choi, H.; Baek, I.; Park, S.A.; Kim, Y.S.; Park, J.; Kim, T.; Jeun, S. HLA Polymorphisms and Risk of Glioblastoma in Koreans. Preprints 2021, 2021030280 (doi: 10.20944/preprints202103.0280.v1).

Abstract

Purpose Immune responses for cancer cells can be altered according to genetic variation of human leukocyte antigen (HLA). Association of HLA polymorphism with risk of various cancer types is well known. However, the association between HLA and glioblastoma (GBM) remains uncertain. We sought to evaluate the association of HLA polymorphism with risk of GBM development in Koreans. Materials and Methods A case-control study was performed to identify the odds ratios (OR) of HLA class I and II genes for GBM. The control group consisted of 142 healthy Korean volunteers, and the GBM group was 80 patients with newly diagnosed GBM at our institution. HLA class I (-A, -B, and –C) and class II (-DR, -DQ, and –DP) genotyping was performed by high-resolution polymerase chain reaction (PCR)-sequence-based typing (PCR-SBT) methods. Results There were significantly decreased frequencies of HLA-A*26:02 (OR 0.22 CI 0.05-0.98), HLA-C*08:01 (OR 0.29 CI 0.10-0.87), and HLA-DRB1*08:03 (OR 0.32 CI 0.11-0.98), while there was significantly increased frequency of HLA-C*04:01 (OR 2.29 CI 1.05-4.97). In analysis of haplotypes, the frequency of DRB1*14:05-DQB1*05:03 was significantly decreased (OR 0.22 CI 0.05-0.98). Conclusion This study suggests that genetic variations of HLA may affect GBM development in Koreans. Further investigations with larger sample sizes are needed to delineate any potential role of the HLA polymorphisms in the pathogenesis of GBM development.

Keywords

HLA; MHC; glioblastoma; immunogenetics; Koreans

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our diversity statement.

Leave a public comment
Send a private comment to the author(s)
Views 0
Downloads 0
Comments 0
Metrics 0


×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.