Version 1
: Received: 25 February 2021 / Approved: 26 February 2021 / Online: 26 February 2021 (15:34:31 CET)
How to cite:
Mitroshina, E.; Savyuk, M.; Ponimaskin, E.; Vedunova, M. HypoxiaInducible Factor (HIF) in Ischemic Stroke and Neurodegenerative Disease. Preprints2021, 2021020624
Mitroshina, E.; Savyuk, M.; Ponimaskin, E.; Vedunova, M. HypoxiaInducible Factor (HIF) in Ischemic Stroke and Neurodegenerative Disease. Preprints 2021, 2021020624
Mitroshina, E.; Savyuk, M.; Ponimaskin, E.; Vedunova, M. HypoxiaInducible Factor (HIF) in Ischemic Stroke and Neurodegenerative Disease. Preprints2021, 2021020624
APA Style
Mitroshina, E., Savyuk, M., Ponimaskin, E., & Vedunova, M. (2021). HypoxiaInducible Factor (HIF) in Ischemic Stroke and Neurodegenerative Disease. Preprints. https://doi.org/
Chicago/Turabian Style
Mitroshina, E., Evgeni Ponimaskin and Maria Vedunova. 2021 "HypoxiaInducible Factor (HIF) in Ischemic Stroke and Neurodegenerative Disease" Preprints. https://doi.org/
Abstract
Hypoxia is one of the most common pathological conditions which results from ischemic injury, trauma, inflammatory conditions, tumors, The adaptation of the body to hypoxia is a phenomenon that is of great importance both in normal conditions and in Most of the cellular response’ reactions to hypoxia is associated with a family of transcription factors called hypoxia-inducible factors (HIF). They induce the expression of a wide range of genes that help cells adapt to a hypoxic HIF functions are currently being extensively studied. In 2019, William G. Kaelin and Gregg Semenza from the USA and Sir Peter J. Ratcliffe from the UK received the Nobel Prize in Physiology or Medicine for the discovery of the basic mechanisms of adaptation to hypoxia and investigation of the role of HIF factor in the regulation of the hormone erythropoietin Based on its pivotal physiological importance, the HIF factor attracts more and more attention as a new potential target for treating a large number of diseases associated with Most of the experimental work dealing with the HIF factor is focused on its role in liver and However, increasing amount of experimental results clearly demonstrates that the HIF factor-based response represents an universal adaptation mechanism for all kinds of tissues, including the nervous system where HIF is critical for regulating neurogenesis, nerve cell differentiation, and neuronal This review provides actual overview about the complex role of HIF-1 in the adaptation of nerve cells to hypoxia with the focus on its potential role by various neuronal
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
