Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Non-Coding RNA Signatures of B-Cell Acute Lymphoblastic Leukemia

Version 1 : Received: 16 February 2021 / Approved: 22 February 2021 / Online: 22 February 2021 (16:33:30 CET)

How to cite: Rodriguez, P.D.; Paculova, H.; Kogut, S.; Heath, J.; Schjerven, H.; Frietze, A.S. Non-Coding RNA Signatures of B-Cell Acute Lymphoblastic Leukemia. Preprints 2021, 2021020496 (doi: 10.20944/preprints202102.0496.v1). Rodriguez, P.D.; Paculova, H.; Kogut, S.; Heath, J.; Schjerven, H.; Frietze, A.S. Non-Coding RNA Signatures of B-Cell Acute Lymphoblastic Leukemia. Preprints 2021, 2021020496 (doi: 10.20944/preprints202102.0496.v1).

Abstract

Non-coding RNAs (ncRNAs) comprise a diverse class of non-protein coding transcripts that regulate critical cellular processes associated with cancer. Advances in RNA-sequencing (RNA-Seq) have led to the characterization of non-coding RNA expression across different types of human cancers. Through comprehensive RNA-Seq profiling, a growing number of studies demonstrate that ncRNAs, including long non-coding RNA (lncRNAs) and microRNAs (miRNA), play central roles in progenitor B-cell Acute Lymphoblastic Leukemia (B-ALL) pathogenesis. Furthermore, due to their central roles in cellular homeostasis and their potential as biomarkers, the study of ncRNAs continues to provide new insight into the molecular mechanisms of B-ALL. This article reviews the ncRNA signatures reported for all B-ALL subtypes, focusing on technological developments in transcriptome profiling and recently discovered examples of ncRNAs with biologic and therapeutic relevance in B-ALL.

Subject Areas

non-coding; leukemia; B-cell; RNA-sequencing; small RNA-sequencing

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