Anapc10 Orchestrates the NLRP3 Inflammasome Activation during Cell Cycle Control

Siyu Huang; Pin Wan; Shanyu Huang; Qi Xiang; Ge Yang; Muhammad Shereen; Pan Pan; Weiyong Liu; Kailang Wu; Jianguo Wu

doi:10.20944/preprints202102.0112.v1

Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Version 1 : Received: 2 February 2021 / Approved: 3 February 2021 / Online: 3 February 2021 (10:32:38 CET)

Activation of the NLRP3 inflammasome plays a crucial role in innate immune response. During cell division, the NLRP3 inflammasome activation must be strictly controlled. Here, we discovered the anaphase promoting complex subunit 10 (Anapc10, APC10), a substrate recognition protein of the anaphase promoting complex/cyclosome (APC/C), is a critical mediator of the NLRP3 inflammasome activation. APC10 protein interacts with NLRP3, and co-localizes with NLRP3 protein in the cytoplasm. During interphase, APC10 interacts with NLRP3 to promote the NLRP3 inflammasome activation. During mitosis, APC10 disassociates from the NLRP3 inflammasome to inhibit the inflammatory responses. This study reveals a distinct mechanism by which APC10 serves as a switch of the NLRP3 inflammasome activation during cell cycle.

cell cycle; cell synchronization; pro-inflammatory cytokines; Anaphase promoting complex subunit 10, Anapc10; Anaphase-promoting complex/cyclosome, APC/C; PYRIN domain containing-3, NLRP3; The NLRP3 inflammasome

LIFE SCIENCES, Biochemistry

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Anapc10 Orchestrates the NLRP3 Inflammasome Activation during Cell Cycle Control

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