Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Anapc10 Orchestrates the NLRP3 Inflammasome Activation during Cell Cycle Control

Version 1 : Received: 2 February 2021 / Approved: 3 February 2021 / Online: 3 February 2021 (10:32:38 CET)

How to cite: Huang, S.; Wan, P.; Huang, S.; Xiang, Q.; Yang, G.; Shereen, M.; Pan, P.; Liu, W.; Wu, K.; Wu, J. Anapc10 Orchestrates the NLRP3 Inflammasome Activation during Cell Cycle Control. Preprints 2021, 2021020112 (doi: 10.20944/preprints202102.0112.v1). Huang, S.; Wan, P.; Huang, S.; Xiang, Q.; Yang, G.; Shereen, M.; Pan, P.; Liu, W.; Wu, K.; Wu, J. Anapc10 Orchestrates the NLRP3 Inflammasome Activation during Cell Cycle Control. Preprints 2021, 2021020112 (doi: 10.20944/preprints202102.0112.v1).

Abstract

Activation of the NLRP3 inflammasome plays a crucial role in innate immune response. During cell division, the NLRP3 inflammasome activation must be strictly controlled. Here, we discovered the anaphase promoting complex subunit 10 (Anapc10, APC10), a substrate recognition protein of the anaphase promoting complex/cyclosome (APC/C), is a critical mediator of the NLRP3 inflammasome activation. APC10 protein interacts with NLRP3, and co-localizes with NLRP3 protein in the cytoplasm. During interphase, APC10 interacts with NLRP3 to promote the NLRP3 inflammasome activation. During mitosis, APC10 disassociates from the NLRP3 inflammasome to inhibit the inflammatory responses. This study reveals a distinct mechanism by which APC10 serves as a switch of the NLRP3 inflammasome activation during cell cycle.

Subject Areas

cell cycle; cell synchronization; pro-inflammatory cytokines; Anaphase promoting complex subunit 10, Anapc10; Anaphase-promoting complex/cyclosome, APC/C; PYRIN domain containing-3, NLRP3; The NLRP3 inflammasome

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