Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

The Effect of Antiglaucoma Procedures (Trabeculectomy vs. Ex-PRESS Glaucoma Drainage Implant) on the Corneal Biomechanical Properties

Aristeidis Konstantinidis
* ORCID logo ,
Eirini - Kanella Panagiotopoulou
,
Georgios Panos
ORCID logo ,
Haris Sideroudi
,
Aysel Mehmet
,
Vasillios Kozobolis
,
Georgios Labiris
Version 1 : Received: 3 January 2021 / Approved: 5 January 2021 / Online: 5 January 2021 (10:38:07 CET)

A peer-reviewed article of this Preprint also exists.

Konstantinidis, A.; Panagiotopoulou, E.-K.; Panos, G.D.; Sideroudi, H.; Mehmet, A.; Labiris, G. The Effect of Antiglaucoma Procedures (Trabeculectomy vs. Ex-PRESS Glaucoma Drainage Implant) on the Corneal Biomechanical Properties. J. Clin. Med. 2021, 10, 802. Konstantinidis, A.; Panagiotopoulou, E.-K.; Panos, G.D.; Sideroudi, H.; Mehmet, A.; Labiris, G. The Effect of Antiglaucoma Procedures (Trabeculectomy vs. Ex-PRESS Glaucoma Drainage Implant) on the Corneal Biomechanical Properties. J. Clin. Med. 2021, 10, 802.

Abstract

The aim of this study is to investigate the effect of two antiglaucoma procedures, namely trabeculectomy and Ex-PRESS mini-shunt insertion on the biomechanical properties of the cornea. This is a prospective study. Thirty patients (30 eyes) were included in the study. Nineteen eyes had an Ex-PRESS shunt inserted (Group 1) and 11 had trabeculectomy (Group 2). The examination time points for both groups were 1 to 3 weeks preoperatively and at month 1, 6 and 12 postoperatively. Corneal biomechanical properties [corneal hysteresis (CH) corneal resistance factor (CRF)] were measured with the Ocular Response Analyzer. In group 1, CH was significantly increased at 6 and 12 months compared to baseline values. Corneal hysteresis was also higher at 1 month postoperatively but this increase did not reach statistical significance. In group 2, the CH was significantly increased at all time points compared to the preoperative values. CRF decreased at all time points postoperatively compared to the preoperative values in both groups. The difference (preoperative values to postoperative values at all time points) of the CH and CRF between the two groups was also compared and no significant differences were detected between the two surgical techniques. Trabeculectomy and the EX-PRESS mini-shunt insertion alter significantly the corneal biomechanical properties as a result of the surgical trauma and the presence of the shunt in the corneal periphery. When compared between them they affect the corneal biomechanical properties in a similar way.

Keywords

glaucoma; trabeculectomy; corneal hysteresis; corneal resistance factor

Subject

Medicine and Pharmacology, Immunology and Allergy

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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