Viral-Vector Delivered anti-Angiogenic Therapies to the Eye

Sanna Koponen; Emmi Kokki; Kati Kinnunen; Seppo Ylä-Herttuala

doi:10.20944/preprints202012.0602.v1

Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Version 1 : Received: 22 December 2020 / Approved: 23 December 2020 / Online: 23 December 2020 (17:45:44 CET)

Pathological vessel growth harms vision and may finally lead to vision loss. Anti-angiogenic gene therapy with viral vectors for ocular neovascularization has shown great promise in pre-clinical studies. Most of the studies has conducted with different adeno-associate serotype vectors. In addition, Adeno and lentivirus vectors have been used. Therapy has targeted to block vascular endothelial growth factors or other pro-angiogenic factors. Clinical trials of intraocular gene therapy for neovascularization have shown the treatment to be safe without severe adverse events or systemic effects. Nevertheless, clinical studies have not proceeded phase 2 trials further.

Gene therapy; ocular neovascularization; viral vectors; preclinical; clinical trials; anti-angiogenesis; AAV

LIFE SCIENCES, Biochemistry

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Viral-Vector Delivered anti-Angiogenic Therapies to the Eye

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