Preprint Case Report Version 1 Preserved in Portico This version is not peer-reviewed

Treatment of Covid-19 with Minocycline and a Guanosine-Restricted Diet: Case Report

Version 1 : Received: 18 December 2020 / Approved: 23 December 2020 / Online: 23 December 2020 (15:58:38 CET)

How to cite: Baranowitz, S.; Nrekaj, M. Treatment of Covid-19 with Minocycline and a Guanosine-Restricted Diet: Case Report. Preprints 2020, 2020120596 (doi: 10.20944/preprints202012.0596.v1). Baranowitz, S.; Nrekaj, M. Treatment of Covid-19 with Minocycline and a Guanosine-Restricted Diet: Case Report. Preprints 2020, 2020120596 (doi: 10.20944/preprints202012.0596.v1).

Abstract

We report the treatment of a 21-year-old female Covid-19 patient by a novel combination of minocycline and a guanosine-restricted diet. Minocycline is an antibiotic with well documented broad spectrum anti-viral effects, including evidence of activity against SARS-CoV-2. Deprivation of guanosine has been documented as an effective anti-viral modality in vitro and in animal models, and specific in vitro activity against CoV-SARS-2 has been reported. The patient's symptoms resolved rapidly.

Keywords

Covid-19, SARS-CoV-2, drug repurposing

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