Preprint Review Version 2 Preserved in Portico This version is not peer-reviewed

An Update on the Chemistry, Pharmacology and Dose Calculations of Mepivacaine Hydrochloride for Podiatrists in the United Kingdom

Version 1 : Received: 18 December 2020 / Approved: 22 December 2020 / Online: 22 December 2020 (10:51:11 CET)
Version 2 : Received: 15 January 2021 / Approved: 19 January 2021 / Online: 19 January 2021 (10:39:01 CET)

How to cite: Reilly, I.; Burt, N.; Reilly, R.; Swami, A. An Update on the Chemistry, Pharmacology and Dose Calculations of Mepivacaine Hydrochloride for Podiatrists in the United Kingdom. Preprints 2020, 2020120555 (doi: 10.20944/preprints202012.0555.v2). Reilly, I.; Burt, N.; Reilly, R.; Swami, A. An Update on the Chemistry, Pharmacology and Dose Calculations of Mepivacaine Hydrochloride for Podiatrists in the United Kingdom. Preprints 2020, 2020120555 (doi: 10.20944/preprints202012.0555.v2).

Abstract

Local anaesthetic agents suppress action potentials in excitable tissues by blocking voltage-gated sodium channels. In doing so they inhibit the depolarisation of nociceptive nerve fibres and so prevent the transmission of pain impulses. UK legislation allows HCPC-registered Podiatrists with POM-A annotation access to six local anaesthetic drugs and two of these with the addition of adrenaline. The use of local anaesthetia has transformed the treatment of nail pathology by Podiatrists. In the UK, the drug of choice in podiatric practice is 3% mepivacaine hydrochloride: it is a good choice of drug for digital anaesthesia. This paper will review the chemistry, pharmacology and dose calculation of mepivacaine, and challenge some of the orthodoxy over the rigid calculation of maximum safe dosages.

Keywords

Mepivacaine; Scandonest; local anaesthesia; pharmacology; maximum safe dose; podiatry

Comments (1)

Comment 1
Received: 19 January 2021
Commenter: Ian Reilly
Commenter's Conflict of Interests: Author
Comment: One new reference and 2 amendments to reference format (dat error/order)
Major reformat of style - much more redable and aesthetic (as required for sumbisison to JCM)
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