Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Clinical and Pathological Correlation between SARS-CoV-2 Infection with Coexisting Health Conditions: A Review

Version 1 : Received: 13 December 2020 / Approved: 14 December 2020 / Online: 14 December 2020 (18:16:00 CET)

How to cite: Saha, R.; Mukhopadhyay, M.; Bhattacharya, D. Clinical and Pathological Correlation between SARS-CoV-2 Infection with Coexisting Health Conditions: A Review. Preprints 2020, 2020120356 (doi: 10.20944/preprints202012.0356.v1). Saha, R.; Mukhopadhyay, M.; Bhattacharya, D. Clinical and Pathological Correlation between SARS-CoV-2 Infection with Coexisting Health Conditions: A Review. Preprints 2020, 2020120356 (doi: 10.20944/preprints202012.0356.v1).

Abstract

Globally, the COVID-19 pandemic has brought the world to a standstill with the infected cases surpassing millions. The causative agent of COVID-19, the SARS-CoV-2 is a novel coronavirus that emerged from the wet animal market in Wuhan, China in early December 2019. Soon after, human-to-human transmission increased the rate of infection making the disease widespread with new hotspots emerging around the world.The epidemiological reports based on clinical characteristics including age, gender, symptoms (both severe and non-severe), and the conditions requiring intensive medical care, along with case fatality revealed that people with co-existing health conditions like diabetes, hypertension, cigarette smoking, and others with cardiovascular and kidney diseases were more susceptible to COVID-19 infection with poor prognosis in cases related to the severity of symptoms and requiring ICU, medical ventilators with a high fatality rate. Even people with immunosuppressed conditions like HIV and cancer, alongwith old age and pregnant women are vulnerable to COVID-19 infection and can cause severe health complications.It is extremely important to have a comprehensive idea of the underlying pathophysiology related to these health conditions which makes them more susceptible to contract SARS-CoV-2 infection in correlation with the development of severe symptoms. This review will provide an extensive viewpoint related to COVID-19 patients having coexisting health conditions together with the association between the prognosis of the disease and the pathogenesis of the SARS-CoV-2 infection, based on the current information available.

Subject Areas

COVID-19; SARS-CoV-2; Comorbidities; Clinical characteristics; Pathobiology; 2019-nCov

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