Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Recent Advances in Trop 2 Targeted Therapy for Solid Tumors

Version 1 : Received: 27 November 2020 / Approved: 2 December 2020 / Online: 2 December 2020 (12:35:36 CET)

How to cite: Liao, S.; Wang, B.; Zeng, R.; Bao, H.; Chen, X.; Dixit, R.; Xing, X. Recent Advances in Trop 2 Targeted Therapy for Solid Tumors. Preprints 2020, 2020120062 (doi: 10.20944/preprints202012.0062.v1). Liao, S.; Wang, B.; Zeng, R.; Bao, H.; Chen, X.; Dixit, R.; Xing, X. Recent Advances in Trop 2 Targeted Therapy for Solid Tumors. Preprints 2020, 2020120062 (doi: 10.20944/preprints202012.0062.v1).

Abstract

Trophoblast cell-surface antigen 2 (Trop 2) is a transmembrane glycoprotein that is highly expressed in various cancer types with relatively low or no baseline expression in most of normal tissues. Its overexpression is associated with tumor growth and poor prognosis; Trop 2 is therefore, an ideal therapeutic target for epithelial cancers. Several Trop 2 targeted therapeutics have recently been developed for the treatment of cancers, such as anti-Trop 2 antibodies and antibody-drug conjugates (ADCs), as well as Trop 2-specific cell therapy. In particular, the safety and clinical benefit of Trop 2-based ADCs have been demonstrated in clinical trials across multiple tumor types, including those with limited treatment options, such as triple-negative breast cancer, platinum-resistant urothelial cancer, and heavily pretreated non-small cell lung cancer. In this review, we elaborate on recent advances in Trop 2 targeted modalities and provide an overview of novel insights for future developments in this field.

Subject Areas

Trop 2; targeted therapy; antibody-drug conjugate; solid tumors

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