Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Renal Involvement in IgA Vasculitis; Possible Correlation with Positive Antiphospholipid Antibodies

Version 1 : Received: 30 November 2020 / Approved: 2 December 2020 / Online: 2 December 2020 (10:36:58 CET)

How to cite: Hassas Yeganeh, M.; Yaraghi, A.; Salehi, S.; Rahmani, K.; Javadi, V.; Shiari, R.; Hosseinzadeh, H. Renal Involvement in IgA Vasculitis; Possible Correlation with Positive Antiphospholipid Antibodies. Preprints 2020, 2020120055 (doi: 10.20944/preprints202012.0055.v1). Hassas Yeganeh, M.; Yaraghi, A.; Salehi, S.; Rahmani, K.; Javadi, V.; Shiari, R.; Hosseinzadeh, H. Renal Involvement in IgA Vasculitis; Possible Correlation with Positive Antiphospholipid Antibodies. Preprints 2020, 2020120055 (doi: 10.20944/preprints202012.0055.v1).

Abstract

IgA vasculitis is a hypersensitivity vasculitis, which is usually self-limiting. Renal involvement is the most damaging long-term complication of IgA vasculitis, happening in 20% - 100% of cases. Some factors have been reported to be associated with renal involvement in IgA vasculitis; however, no biomarker has been proved as a risk factor for renal involvement and its severity yet. We followed 48 patients with a confirmed diagnosis of IgA vasculitis for six months. We checked these patients for renal involvement by microscopic urine examination. We checked aPL antibodies in all patients on admission and 12 weeks later. Urinalysis showed renal involvement in 14 of 48 patients with IgA vasculitis (29.16%). Antiphospholipid antibodies were positive in 9 patients with IgA vasculitis and renal involvement (9 out of 14, 64.28%), while they were positive in only six patients with IgA vasculitis without renal involvement (6 out of 34, 17.64%), showing a moderate correlation between positive aLP and renal involvement in patients with IgA vasculitis, with a kappa index of 0.457. Serum aPL antibodies, as a tool to predict renal involvement in IgA vasculitis, show a sensitivity of 64.3%, a specificity of 82.4%, PPV of 60.0%, and NPV of 84.8%, demonstrating that a positive serum aPL antibody can be used to positively predict the renal involvement, while a negative result is not strong enough to rule out future renal involvement.

Keywords

IgA vasculitis; antiphospholipid antibodies; lupus anticoagulant; anticardiolipin antibodies; anti-b2 glycoprotein antibodies

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our diversity statement.

Leave a public comment
Send a private comment to the author(s)
Views 0
Downloads 0
Comments 0
Metrics 0


×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.