Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Diagnostic Task Specific Activations in Functionoal Mri and Aberrant Connectivity of Insula with Middle Frontal Gyrus Can Inform the Differential Diagnosis of Psychosis

Drozdstoy Stoyanov
* ,
Katryn Aryutova
ORCID logo ,
Sevdalina Kandilarova
,
Rositsa Paunova
,
Zlatoslav Arabadzhiev
,
Anna Todeva
,
Stefan Kostianev
,
Stefan Borgwardt
Version 1 : Received: 30 November 2020 / Approved: 1 December 2020 / Online: 1 December 2020 (14:51:43 CET)

A peer-reviewed article of this Preprint also exists.

Stoyanov, D.; Aryutova, K.; Kandilarova, S.; Paunova, R.; Arabadzhiev, Z.; Todeva-Radneva, A.; Kostianev, S.; Borgwardt, S. Diagnostic Task Specific Activations in Functional MRI and Aberrant Connectivity of Insula with Middle Frontal Gyrus Can Inform the Differential Diagnosis of Psychosis. Diagnostics 2021, 11, 95. Stoyanov, D.; Aryutova, K.; Kandilarova, S.; Paunova, R.; Arabadzhiev, Z.; Todeva-Radneva, A.; Kostianev, S.; Borgwardt, S. Diagnostic Task Specific Activations in Functional MRI and Aberrant Connectivity of Insula with Middle Frontal Gyrus Can Inform the Differential Diagnosis of Psychosis. Diagnostics 2021, 11, 95.

Abstract

We constructed a novel design integrating the administration of a clinical self-assessment scale with simultaneous acquisition of functional Magnetic Resonance Imaging (fMRI), aiming at cross-validation between psychopathology evaluation and neuroimaging techniques. We hypothesized that areas demonstrating differential activation in two groups of patients (paranoid and depressive) will have distinct connectivity patterns and structural differences.

Keywords

neuropsychiatric disorders;translational neuroscience; neuroimaging; brain networks; connectivity; schizophrenia; depression; precuneus; insula; frontal cortex; default mode network

Subject

Medicine and Pharmacology, Immunology and Allergy

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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