Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Diagnostic Task Specific Activations in Functionoal Mri and Aberrant Connectivity of Insula with Middle Frontal Gyrus Can Inform the Differential Diagnosis of Psychosis

Version 1 : Received: 30 November 2020 / Approved: 1 December 2020 / Online: 1 December 2020 (14:51:43 CET)

A peer-reviewed article of this Preprint also exists.

Stoyanov, D.; Aryutova, K.; Kandilarova, S.; Paunova, R.; Arabadzhiev, Z.; Todeva-Radneva, A.; Kostianev, S.; Borgwardt, S. Diagnostic Task Specific Activations in Functional MRI and Aberrant Connectivity of Insula with Middle Frontal Gyrus Can Inform the Differential Diagnosis of Psychosis. Diagnostics 2021, 11, 95. Stoyanov, D.; Aryutova, K.; Kandilarova, S.; Paunova, R.; Arabadzhiev, Z.; Todeva-Radneva, A.; Kostianev, S.; Borgwardt, S. Diagnostic Task Specific Activations in Functional MRI and Aberrant Connectivity of Insula with Middle Frontal Gyrus Can Inform the Differential Diagnosis of Psychosis. Diagnostics 2021, 11, 95.

Journal reference: Diagnostics 2021, 11, 95
DOI: 10.3390/diagnostics11010095

Abstract

We constructed a novel design integrating the administration of a clinical self-assessment scale with simultaneous acquisition of functional Magnetic Resonance Imaging (fMRI), aiming at cross-validation between psychopathology evaluation and neuroimaging techniques. We hypothesized that areas demonstrating differential activation in two groups of patients (paranoid and depressive) will have distinct connectivity patterns and structural differences.

Subject Areas

neuropsychiatric disorders;translational neuroscience; neuroimaging; brain networks; connectivity; schizophrenia; depression; precuneus; insula; frontal cortex; default mode network

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